Nutritional alterations, mineral deficiency
Conditions
Interventions
The study will consist of 40 participants of both sexes, in continuous use of Statin. Individuals will be divided into two groups, Group 1 (G1) will be composed of 20 individuals with muscular disorde
selenium and selenometabolites
glutathione peroxidase activity
C-reactive protein
oxidative stress
gene expression and polymorphisms in selenoproteins
Dietary supplement
SP6.051.227
Sponsors
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Eligibility
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Adults subjects of both sexes; in chronic use of Statins; with muscle disorders in the case of individuals in the study group; no muscle disorders in the case of individuals in control group
Exclusion criteria
Exclusion criteria: Presence of serious cardiac complications or other diseases such as thyroid; hematological; congenital; autoimmune; liver disease; renal failure; cancer; associated infections; osteoporosis; postoperative; antibiotics and vitamin and mineral supplements; food allergy to oilseed; current alcoholism and smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase in the gene expression of selenoproteins by means of the real-time polymerase chain reaction method, based on the observation of a variation of at least 15% in the measurements before and after supplementation with brazil nuts | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected | — |
Countries
Brazil
Contacts
Public ContactAnderson Marliere Navarro
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Outcome results
None listed