Other primary knee osteoarthritis
Conditions
Interventions
This study is a prospective, randomized clinical trial aimed at evaluating the effects of using bone marrow aspirate and concentrated bone marrow aspirate compared to the bone marrow aspirate matrix (
Sponsors
Faculdade de Medicina da Universidade Federal Fluminense
Hospital Universitário Antonio Pedro/Empresa Brasileira de Serviços Hospitalares
Eligibility
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age between 50 and 70 years old; both sexes; diagnosis of Bilateral Osteoarthritis of the knee, according to the criteria of the American College of Rheumatology; radiographs with a Kellgren-Lawrence classification higher than III in both knees; present full range of motion (0 to 120°)
Exclusion criteria
Exclusion criteria: History of previous trauma, infection or surgery in the same knee in the last 2 years;limb malalignment (varus>10º and valgus > 15º);corticosteroid infiltration in the same knee in the last 3 months;hyaluronic acid ; unfiltration in the same knee in the last 12 months;inflammatory, autoimmune or neoplasic disease;body mass index> 35 kg/m2; use of immunosuppressants or anticoagulants; active neoplasia; hematologic disorders; history of transmissible disease accute or chronic; living outside Rio de Janeiro metropolitan area; participants without full autonomy, blind, deaf or illiterate; patients unable for positioning; patients using statins
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A 1.5 difference in pain analysed by visual analog scale is expected. | — |
Secondary
| Measure | Time frame |
|---|---|
| An improvement of 20% in function analysed by WOMAC (Western Ontario and McMaster Univesities Osteoarthritis Index) and KSS (Knee Society Score) is expected. | — |
Countries
Brazil
Contacts
Public ContactEduardo de Sousa
Universidade Federal Fluminense
Outcome results
None listed