Wounds
Conditions
Interventions
Topical application of local anesthetic:
Group 1: 30 healthy volunteers received once in the bucal mucosa in one session EMLA® (2.5% of lidocaine and 2.5 % of prilocaine)- 60 mg
Group 2: 30 healthy volunteers received once in the bucal mucosa in one session EMLA® (2.5% of lidocaine and 2.5 % of prilocaine)- 10 mg
Group 3: 30 healthy volunteers received once in the bucal mucosa in one session Bioadhesive with 2.5% of lidocaine and 2.5 % of prilocaine- 10 mg
Group 4: 30 healthy volunteers received once in the b
Drug
E01.370.600.550.324
Sponsors
Universidade São Francisco
Universidade São Francisco
Eligibility
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Age 20 to 45 years; Healthy; Students form graduation or post graduation from Universidade São Francisco or Universidade Estadual de Campinas; only the subjects having the upper right canine free of caries, large restorations, periodontal disease, past endodontic treatment, oral mucosal with no trauma or sensitivity were included.
Exclusion criteria
Exclusion criteria: Allergy to local anesthetic; cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal and hematological diseases, psychiatric disorders; use of any medication, except oral contraceptives one week prior or during the experiment; smokers; addictive behavior with drugs or alcohol; pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To obtain safer and more effective local anesthesia when compared to the commercial formulation (EMLA) determined by pulpal and oral mucosal sensibility test, and also by plasma levels of the local anesthetics. ;Bioadhesive formulation was able to promote soft tissue anesthesia equivalent to EMLA® when used at two different doses (10 and 60 mg). Theses formulations presented lower systemic absorption. | — |
Countries
Brazil
Contacts
Public ContactGiovana Tofoli
Faculdade São Leopoldo Mandic
Outcome results
None listed