Hematological malignancies
Conditions
Interventions
The sample is non-probabilistic, by convenience and the sample size will be achieved by temporal saturation. Therefore, the data that will be submitted to analysis will be related to the sample obtain
Intervention: orally supplemented with fish oil gelatinous capsule (2g/kg/day) for nine weeks. All additional procedures will be the same for both groups of participants.
Dietary supplement
Sponsors
Universidade Federal de Santa Catarina
Universidade Federal de Santa Catarina
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Eligibility
Age
16 Years to 90 Years
Inclusion criteria
Inclusion criteria: Aged 16 years old or more; present hematologic malignancy diagnosis, be able to start chemotherapy; present adequate oral intake conditions; accept to participate of anthropometric and biochemical evaluations, indicating your acceptance by signing the Free and Clarified Consent Term. Additionally, individuals under the age of 18,will be included in the study only after signed parental consent.
Exclusion criteria
Exclusion criteria: Aged less than 16 years old, no legal parental consent if under 18 years old, to be in palliative care; receiving statins and/or some nonsteroidal anti-inflammatory drug; possess any infectious disease diagnosis, be allergic to fish and/or derivatives, have made use of fish oil and/or other supplements containing omega-3 six months before the beginning of the study or being pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease of the Inflammatory-Nutritional risk indicated by C-reactive protein/Albumin: Calculated by the ratio of the Serum C-reactive protein (mg/L) by the serum albumin (g/dL) Both are determined in serum obtained from blood by an automated biochemistry analyzer. Classification adopted: without risk: 2.0 After the calculation of the ratio, the intragroup (basal and after nine weeks) and intergroup (control vs. supplemented) values (means or medians) are compared. Additionally, the number of subjects presenting changes in the risk classification are compared between time points and groups of study. | — |
Secondary
| Measure | Time frame |
|---|---|
| Increase in the Nutritional Risk Index (NRI): Calculated based on the equation: 1.519 x serum albumin (g/dL) + 41.7 x current weight (kg)/usual weight (kg) Serum albumin is determined by an automated colorimetric method, current weight by an electronic platform scale on the days of blood colletion and usual weight (from the last 6 months) is auto-reported The classification adopted: No nutrition risk: >100; Borderline nutrition risk: 99.9-97.5; Mild nutrition risk: 83.5-97.5; Severe nutritional risk: <83.5 The intragroup (basal and after nine weeks) and intergroup (control vs. supplemented) values (means or medians) are compared. Additionally, the number of subjects that presenting changes in the risk classification are compared between time points and groups of study | — |
Countries
Brazil
Contacts
Public ContactEverson Nunes
Universidade Federal de Santa Catarina
Outcome results
None listed