Polycystic Ovary Syndrome
Conditions
Interventions
97 women, 45 with polycystic ovary syndrome (PCOS) and 52 healthy women, participated in a linear periodization of physical training for a period of 4 months, three times per week, during 1 hour, prec
Procedure/surgery
G11.427.590.530.698.277
Sponsors
Faculdade de Medicina de Ribeirão Preto
Faculdade de Medicina de Ribeirão Preto
Eligibility
Sex/Gender
Female
Age
18 Years to 37 Years
Inclusion criteria
Inclusion criteria: Age between 18 to 37 years; Body Mass Index between 18 and 39.9 kg/m2 (normal overweight and obesity grades I and II);do not practice regular physical activity.
Exclusion criteria
Exclusion criteria: Presence of systemic disease that indicate against the practice of physical activity; presence of disabling musculoskeletal disorders; use of drugs that interfere with the hypothalamic-pituitary ovarian axis and hormonal contraceptives; smoking; pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)- Increased muscle strength in all subjects, verified by comparative analysis before and after a period of four months of intervention with the protocol of physical resistance training. - Women with polycystic ovary syndrome, because they are hyperandrogenic, have more muscle strength than women with regular menstrual cycles. - The periodized physical exercise improved body composition and increased telomere length in leukocytes. 2)To measure the outcome, the one repetition maximum (1-RM) test was employed as a noninvasive measure of muscle strength. These test was conducted after two weeks of familiarisation, in which four exercises were performed per day, being separated by two days or 48 hours, for muscle recovery and avoiding influences from other exercises on testing. Body composition was assessed by bone densitometry (X-ray Dual-energy absorptiometry, DXA) and telomere length was measured by Real Time Polymerase Chain Reaction. 3) To investigate outcomes, considering a 10% difference in muscle strength between in groups, with 80% power and alpha = 0.05, 120 participants would be needed, considering previously published studies to muscle strength in young women: bench press = 29.54 ± 5,37kg (mean ± standard deviation); leg extension = 41.09 ± 18,78kg; barbell and 16.00 ± 3.13. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Body Composition Measurement 2) Body Composition was evaluated by Dual-energy X-ray absorptiometry (DEXA), bioimpedance and skinfold thickness measurement. 3)The periodized physical resistance exercise improved body composition regardless of whether or not the polycystic ovary syndrome (PCOS), and PCOS patients had a reduction of central fat (distribution of gynoide fat);1) Telemere Lenght Measurement 2) Telomere length was measured by Quantitative Real Time Polymerase Chain Reaction (qPCR). 3) Telomere length was reduced after Physical Resistance Training considering all women in the present study, regardless of whether or not the polycystic ovary syndrome (PCOS);1) Quality of life 2) Quality of life was verified by Short Form Health Survey (SF36), Index of Female Sexual Function (IFSF) and Hospital Anxiety and Depression Scale (HADS) 3) After physical resistance training there was an improvement in quality of life, although this benefit has not persisted after discontinuation of training. | — |
Countries
Brazil
Contacts
Public ContactRosana dos Reis
Faculdade de Medicina de Ribeirão Preto
Outcome results
None listed