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Effects of treatment with oral anticoagulant associated with antibiotic therapy in Covid-19

Effects of treatment with oral anticoagulant associated with antibiotic therapy on clinical, immunological parameters, hospitalization and mortality in patients with suspected Covid-19 infection and positive d-dimer: a randomized clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7nzwkpg
Enrollment
Unknown
Registered
2021-01-06
Start date
2021-09-30
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid-19

Interventions

Control group (n= 80): each patient will receive one non-transparent bottle, containing 28 non-transparent capsules. The capsules will contain standard placebo formulation, consisting of 0.5% magnesiu

Sponsors

Universidade do Sul de Santa Catarina
Lead Sponsor
Universidade do Sul de Santa Catarina
Collaborator

Eligibility

Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Patients over 18 years of age; clinical suspicion of Covid-19; oxygen saturation between 93% and 97%; at least one more symptom according to the Ministry of Health criteria including tiredness or shortness of breath; fever and chills reported; cough and loss of smell or taste; positive result for the D-dimer test

Exclusion criteria

Exclusion criteria: Patients with active infectious diseases; immunosuppressive diseases or active cancer; pregnant or lactating women; known renal failure; current use of anticoagulants; contraindication to the use of Edoxaban or Moxifloxacin

Design outcomes

Primary

MeasureTime frame
frequency of individuals who required hospitalization after starting treatment (in %)

Secondary

MeasureTime frame
Secondary outcomes are not expected

Countries

Brazil

Contacts

Public ContactAnna Piovezan
anna.piovezan@unisul.br+55(48)999382690

Outcome results

None listed

Source: REBEC (via WHO ICTRP)