Epilepsy
Conditions
Interventions
Retrospective study that included sequentially seven patients with hypothalamic hamartoma, who were submitted to radiofrequency ablation. Clinical evaluation and follow-up were held using related epil
Procedure/surgery
Sponsors
Universidade de São Paulo
Universidade de São Paulo
Eligibility
Age
13 Years to 50 Years
Inclusion criteria
Inclusion criteria: Age between 13 and 50 years old, hypothalamic hamartoma identified on magnetic ressonance imaging and presence of refractory gelastic seizures
Exclusion criteria
Exclusion criteria: Alcohol Abuse, medication, or dependence on illicit substances in the Last 12 Months, clinically relevant lesions (other tumors than hypothalamic hamartoma, for example) in preoperative magnetic resonance imaging, patients undergoing chemotherapy for treatment of malignant tumors or who require chronic oral or intravenous treatment with immunosuppressants or steroids, patients unable to comply with schedule of study visits and timetable, lactating patients or with positive pregnancy test, other medical conditions that require probable hospitalization during the study, cronic infection, to have any metallic implant in the brain and current participation in another study of device investigation or drugs testing or surgeries of any nature.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Control evaluation of gelastic and non gelastic seizures. | — |
Secondary
| Measure | Time frame |
|---|---|
| Volumetric and morphological evaluation through magnetic resonance imaging.;Evaluation of the hormonal profile through the serum dosage.;Evaluation of the global improvement measured by the Global Clinical Impression scale. | — |
Countries
Brazil
Contacts
Public ContactMiguel Ernesto San Martin Sepulveda
Universidade de São Paulo
Outcome results
None listed