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Effects of levodopa on masticatory and oral sensory function in Parkinson’s Disease

Oral health and chewing function in patients with Parkinson’s Disease

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
REBEC
Registry ID
RBR-7k4ttg
Enrollment
Unknown
Registered
2018-05-10
Start date
2016-06-10
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease

Interventions

Case group: 12 patients with Parkinson's disease will be evaluated for masticatory function and oral sensory function 1 hour before taking levodopa medication for control of Parkinson's signs and symp
The Masticatory Function will be evaluated by the Masticatory Performance (represented by the value of X50)
by the tracing of the mandibular movements and by the maximum force of bite
The oral sensory function will be evaluated by the oral stereognosis test. The evaluations will be carried out in a period of 1h, in a single day Control group: The same 12 patients with Parkinson's d
Oral health will be evaluated through the GOHAI and OHIP-49 questionnaires
The oral sensory function will be evaluated by the oral stereognosis test
The evaluations will be carried out in a period of 1h, in a single day
Drug
G07.203.650.283.500

Sponsors

Faculdade de Odontologia de Piracicaba
Lead Sponsor
Universidade Estadual de Campinas
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Case group: volunteer with Parkinson's disease; both genders; age over 60 years; edentulous or partially dentate; with and without removable dental prostheses. Control group: Paired study

Exclusion criteria

Exclusion criteria: Case group: volunteers should not have neurodegenerative disease, except for Parkinson's disease; and should not have not neurological disorders in which parkinsonism comprises the clinical condition. Control group: Paired study

Design outcomes

Primary

MeasureTime frame
It will be expected to find an impairment in masticatory function and oral sensory function in the group with Parkinson's disease during the off-period of levodopa; The chewing function is measured by the value of 'X50', and for determining the expected outcome, differences of 2 points in this figure are clinically relevant; The oral sensory function is measured by means of the oral stereognosis test and, to verify the expected outcome, differences of 1.5 points in this value are clinically relevant—

Secondary

MeasureTime frame
Secondary outcomes are not expected—

Countries

Brazil

Contacts

Public ContactGiselle Ribeiro

Faculdade de Odontologia de Piracicaba

giselle.ribeiro1@gmail.com+55-019-2106-5295

Outcome results

None listed

Source: REBEC (via WHO ICTRP)