Asthma
Conditions
Interventions
This is a randomized controlled, double-blind clinical study. A total of 66 children and adolescents, aged between 6 and 20, who meet the eligibility criteria will be allocated probabilistically to on
G07.203.300.456.500
Sponsors
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Eligibility
Age
6 Years to 20 Years
Inclusion criteria
Inclusion criteria: Children and adolescents between 6 and 20 years of age; Diagnosis of mild, moderate or severe persistent asthma, controlled or uncontrolled; Sensitization to at least 1 aeroallergen (prick test or specific IgE) and/or total IgE = 100 kU/L.
Exclusion criteria
Exclusion criteria: Non-agreement to participate by the child/adolescent or parent/guardian; Allergy or serious adverse reaction attributable to the administration of the probiotic mixture or placebo; Failure to administer the medication correctly; Non-adherence to treatment (i.e. not using it regularly, as prescribed) for at least one continuous month; Failure to attend more than 50% of the assessments (clinical and/or laboratory) that will be carried out during the study; Previous known history of allergy to the probiotic mixture; Use of oral corticosteroids, immunosuppressants or immunobiologicals within 30 days prior to recruitment; Other chronic pneumopathies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Favorable clinical response in research participants with asthma, as well as an increase in cytokines responsible for tolerance and a reduction in inflammatory markers. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is hoped to improve the control of other allergic diseases, such as allergic rhinitis and atopic dermatitis, as well as improving the quality of life of the research participant. | — |
Countries
Brazil
Contacts
Public ContactDaniel Neiva
Universidade de São Paulo - Ribeirão Preto
Outcome results
None listed