Male Pattern Baldness
Conditions
Interventions
This is a double-blind, randomized, monocentric clinical trial with a 24-week longitudinal follow-up. Eighty men diagnosed with male androgenetic alopecia were randomly divided into two groups: group
group 2, intervention, received mesotherapy application of 1 ml of DT 0.1% on the scalp every 3 months. Both groups underwent 5 monthly sessions, with patients in group 1 receiving dutasteride every m
Sponsors
Clinica Sanabria Transplante e Restauração Capilar
Hospital Universitário Maria Aparecida Pedrossian da Universidade Federal do Mato Grosso do Sul
Eligibility
Sex/Gender
Male
Age
25 Years to 50 Years
Inclusion criteria
Inclusion criteria: Males; age between 25 and 50 years; diagnosis of male androgenetic alopecia classified as grades 3V, 4V or 5V on the Norwood-Hamilton scale
Exclusion criteria
Exclusion criteria: Patients who present any other causes of hair loss other than exclusively androgenetic alopecia; known hypersensitivity to dutasteride; previous diagnosis of erectile dysfunction; use of therapy aimed at increasing hair density in the last four months; patients with insulin-dependent diabetes mellitus; history of stroke, cancer, thromboembolic phenomena or use of anticoagulant medications; patients with a previous history of psoriasis or lichen planus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find an increase in the density of terminal hairs in the target area in both groups and it is intended to determine whether the increase was greater in the group that received the medication monthly compared to the group that received the medication quarterly. The evaluation will be through trichoscopic photography taken before treatment and after 24 weeks, in the vertex region using Fotofinder equipment, with counting of terminal hairs. This same area was tattooed at two points (north and south) with red ink to ensure the reproducibility of the evaluation. Hairs with a thickness greater than 0.04 mm will be considered terminal hairs. | — |
Secondary
| Measure | Time frame |
|---|---|
| An increase in the total density of hairs in the target area is expected in both groups and it is intended to determine whether the increase was greater in the group that received the medication monthly compared to the group that received the medication quarterly. The evaluation will be through trichoscopic photography taken before treatment and after 24 weeks, in the vertex region using Fotofinder equipment, with counting of the terminal hairs. This same area was tattooed in two points (north and south) with red ink to ensure reproducibility of the evaluation.;Clinical improvement is expected in both groups, and we want to assess whether the improvement was greater in the group receiving the medication monthly compared to the group receiving the medication quarterly. The evaluation will be made by comparing standardized photographs taken before and after 24 weeks of treatment. The standardized photographs will be evaluated by a dermatologist who was not involved in the study and was unaware of the treatment. The dermatologist will compare the initial photograph with the photograph taken after 24 weeks of treatment and will use a 7-point comparison scale: significant worsening (-3), moderate worsening (-2), mild worsening (-1), no change (0), mild improvement (+1), moderate improvement (+2), and significant improvement (+3). | — |
Countries
Brazil
Contacts
Public ContactMarcelo Medeiros
Clinica Sanabria Transplante e Restauração Capilar
Outcome results
None listed