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Effect of Training Functional Activities on biological factors after Stroke

Efficacy of Task-Specific Training in changing neurotrophic factors and impact on clinical outcomes in individuals with Stroke: a randomized controlled trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7hqk8t
Enrollment
Unknown
Registered
2018-01-26
Start date
2018-02-02
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disease of the nervous system Stroke

Interventions

Experimental group: 18 patients with a diagnosis of stroke will perform training for 12 weeks at a frequency of three times a week for 60 minutes, which will involve outreach activities, upper and low
Other
Q65.060
E02.779

Sponsors

Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais
Lead Sponsor
Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Volunteer with clinical diagnosis of primary or recurrent cerebrovascular accident for more than six months; aged 18 years or over; with the capacity to independently roam more than 10 meters with or without gait; sedentary lifestyle or who are insufficiently active; with medical release for the practice of physical activity.

Exclusion criteria

Exclusion criteria: Patients with cognitive impairment (Mental State Examination) will be excluded; with a history of severe heart disease and uncontrolled blood pressure; with presence of pain or pathology that interferes with the intervention, such as vestibular disorders, severe arthritis or any disease of the nervous system; that do not allow or fear the collection of blood; who have made use of anti-inflammatory drugs in the last month.

Design outcomes

Primary

MeasureTime frame
It is expected to find a difference in serum BDNF concentration before and after the 12-week intervention, as measured by the enzyme-linked immunosorbent assay (ELISA), at least 20% according to El-Tamawy et al. (2014).—

Secondary

MeasureTime frame
It is expected to find difference in serum concentration on other neurotrophic factors (Nerve growth factor, NGF; glial cell-derived neurotrophic factor, GDNF). Difference in the mean walking speed in the 10-meter test (self-selected and maximal velocity), mean difference in reaction time in the Timed Up and Go (TUG) test and difference in mean exercise capacity assessed by means of the Test of Six Minutes Walk.—

Countries

Brazil

Contacts

Public ContactPaula Scalzo

Universidade Federal de Minas Gerais

scalzopl@gmail.com55-31-34092799

Outcome results

None listed

Source: REBEC (via WHO ICTRP)