Malignant neoplasm of colon, unspecified
Conditions
Interventions
G11.427.410.698.277
The measurements will be taken before and after 8 weeks of intervention in 20 participants who will be randomly divided in a counterbalanced manner into two groups: Training (TG) and Control (CG). A r
Sponsors
Universidade de São Paulo
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Men and women over the age of 18; diagnosed with colorectal cancer; undergoing chemotherapy treatment; with access to a tablet, smartphone, laptop, or computer with an integrated video camera; and willing to appear on camera during exercise sessions to enable safety monitoring
Exclusion criteria
Exclusion criteria: Diagnosis of cardiovascular disease and neurodegenerative diseases; presenting any other health problem that interferes with the execution of the proposed exercises and evaluations; history of neuromuscular injury in the upper and lower limbs in the last 12 months; not being considered able to participate in the study after medical evaluation; refusing to sign the informed consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| After intervention, we expect a significative increase in the maximum isometric torque (Nm) of knee and elbow extension and flexion, measured by an isokinetic dynamometer equipment (Biodex, System 4 Pro, New York, NY, USA) with an acquisition frequency of 100 Hz. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected that muscle thickness (mm) measured by ultrasound (Saevo, Ultrasound FP 102, Ribeirão Preto, SP, Brazil) will be maintained or possibly significantly increased in the flexor and extensor muscles of the knee and elbow after the intervention.;Electromyographic activity measured by wireless sensors (Trigno Lab Wireless, Delsys Inc., Boston, Massachusetts, USA) is expected to increase significantly after the intervention in the knee and elbow flexor and extensor muscles.;The intervention is expected to alter the expression of microRNAs that will be analyzed by the real-time PCR method.;Quality of life, as assessed by applying the "Functional Assessment of Cancer Therapy Colorectal" (FACT-C, version 4) questionnaire, is expected to improve after intervention.;Cancer-related fatigue, as assessed by the Fatigue Assessment Scale (FAS), is expected to reduce after the intervention. | — |
Countries
Brazil
Contacts
Public ContactRafael;Matheus Fujita;Gomes
Universidade de São Paulo - Escola de Educação Física e Esporte de Ribeirão Preto;Universidade de São Paulo - Escola de Educação Física e Esporte de Ribeirão Preto
Outcome results
None listed