Knee osteoarthritis
Conditions
Interventions
This is a cross-over design (the participants will perform all experimental conditions).The 4 conditions will be performed in a randomized fashion, in a period between 14-28 days.
Experimental condi
Behavioural
G11.427.410.698.277
Sponsors
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)
Faculdade de Medicina, Universidade de São Paulo
Eligibility
Sex/Gender
Female
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: Post-menopausal women between 40-85 years, with knee osteoarthritis according to the criteria proposed by the American College of Rheumatology. The participants should present grade II or III of severity of the osteoarthritis according to Kellgren & Lawrence and pain rated between 2 and 8 in the visual analogue scale.
Exclusion criteria
Exclusion criteria: The participants will be excluded if they present: cardiovascular, pulmonary, metabolic or any other disease that could preclude the procedures; systolic blood pressure greater than 160/105 mmHg; ischemia or arrhythmia during the exercise test; lower limb venous insufficiency; previous thrombosis and/or phlebitis in lower limbs; musculoskeletal impairment that preclude the performance of physical activity; body mass index greater than 35 kg/m2; under use of medications affecting the autonomic nervous system (e.g., beta blockers, and non-dihydropyridine calcium channel blocker); under use of anticoagulants; under glucocorticoid infiltration in the last 3 months; or under use of any glucorticoid in the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Beat-by-beat blood pressure using a photoplethysmographic monitor (Finometer, FMS, Inc., Amsterdam, Netherlands) connected to a finger cuff. This assessment will be performed before, during and after the exercise. ;Endothelial function using a vascular ultrasound and the flow-mediated dilation technique. This assessment will be performed before and after the exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain perception using a visual analogue scale from 0-10. This assessment will be performed before, during and after the exercise. ;Effort perception using the Cr-10 Borg Scale. This assessment will be performed during the exercise.;Pleasure perception using the 11 point bipolar Feeling Scale by Hardy e Rejeski (1989). The scale ranges from +5 (very good) to -5 (very bad). This assessment will be performed during the exercise.;Braquial blood pressure using an oscillometric monitor. This assessment will be performed before, during and after the exercise. ;Heart rate using a electrocardiogram. This assessment will be performed before, during and after the exercise. ;Heart rate variability using a customized software. This assessment will be performed before and after the exercise.;Blood pressure variability using a customized software. This assessment will be performed before and after the exercise.;Baroreflex sensitivity using a customized software. This assessment will be performed before and after the exercise.;Respiratory movements using a piezoelectric belt connected to an amplifier. This assessment will be performed before and after the exercise. | — |
Countries
Brazil
Contacts
Public ContactTiago Peçanha
Faculdade de Medicina, Universidade de São Paulo
Outcome results
None listed