Pulp Necrosis
Conditions
Interventions
Normal pulp group: 2 patients with indication of orthodontic extraction will have the pulp tissue removed for proteomic analysis.
Inflamed pulp group: 2 patients with pulpitis will have their pulps re
Procedure/surgery
E06.397.778
Sponsors
Faculdade de Odontologia de Araçatuba - Universidade Estadual Paulista
Faculdade de Odontologia de Araçatuba - Universidade Estadual Paulista
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: A total of 6 patients were included in this study, 2 with normal pulp (orthodontic indication of extraction), 2 with pulpitis and 2 with chronic apical periodontitis. Therefore, the patients should present the pulp conditions mentioned and for the endodontic treatment of the teeth with inflammation and pulp necrosis, they should be able to be isolated with a rubber dam.
Exclusion criteria
Exclusion criteria: Patients without systemic disease. Patients whose teeth cannot be restored.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in protein expression of normal, inflamed and necrotic pulp tissue through the proteomic analysis of the dental pulp.;In the inflamed pulp group compared to the normal pulp group, the most expressed proteins were hemoglobins, peroxiredoxins and immunoglobulins, while the less expressed were tubulins. While in the necrotic pulp group, the expression of albumins, immunoglobulins and alpha-2-macroglobulin were increased when compared to the inflamed pulp group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected. | — |
Countries
Brazil
Contacts
Public ContactRogério de Castilho Jacinto
Faculdade de Odontologia de Araçatuba - Universidade Estadual Paulista
Outcome results
None listed