Troponin, creatine kinase, blood glucose, blood gas, electrolytes, C-reactive protein, lactate, blood count, total cardioplegia volume and number of doses, total aortic clamp time and extra-corporeal circulation, arrhythmias, acute myocardial infarction, need for hemodynamic support with an intra-aortic balloon, length of time using vasopressors or inotropic solutions, length of stay in the intensive care unit, transfusions of blood products, changes in the postoperative ejection fraction, morta
Conditions
Interventions
Ninety patients will be randomized to receive the solutions of del Nido, del Nido modified with ringer lactate or Brestschneider during cardiopulmonary bypass, 30 for each group. An arterial blood sam
Sponsors
Hospital Nossa Senhora da Conceição
Hospital Nossa Senhora da Conceição
Eligibility
Age
18 Years to 110 Years
Inclusion criteria
Inclusion criteria: Patients referred for elective valve replacement surgery or coronary artery bypass grafting surgery (CABG) with cardiopulmonary bypass, aged at least 18 years, accordance with the Free and Informed Consent Form, will be enrolled.
Exclusion criteria
Exclusion criteria: Patients with chronic renal disease (previous medical diagnosis or serum creatinine greater than 1.5 mg/dL), previous cardiac surgery, severe psychiatric illness, or inability or unwillingness to give informed consent for participation will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression of the cardiac enzymes curve (CK, CK-MB and troponin), determined through laboratory evaluation of arterial blood samples collected in the preoperative period and at 2, 12 and 24 hours after the end of the extracorporeal circulation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative outcomes: total volume of cardioplegia and number of doses, total aortic cross-clamp time, and cardiopulmonary bypass;;Assessments of additional myocardial protection measures: incidence of ventricular fibrillation requiring electrical defibrillation after aortic cross-clamp removal, postoperative changes in the left ventricular ejection fraction (LVEF) and in the ventricular septal function, blood gas analysis, duration of inotrope or vasopressor requirement, and requirement for intra-aortic balloon pump (IABP) support. ;Clinical outcomes: ICU (intensive care unit) stay, prolonged ventilation (>24 h), incidence of postoperative atrial fibrillation or flutter, acute myocardial infarction, mortality, and blood products transfusion;;Progression of the gasometry and CBC elements curve, lactate, C-reactive protein, glycemia and electrolytes, determined through laboratory evaluation of arterial blood samples collected preoperatively and at 2, 12 and 24 hours after the end of extracorporeal circulation. corporeal.;Compare the cost-effectiveness ratio between the solutions.; Comparisons between cardioplegic solutions regarding the prediction of major cardiovascular events in adult patients undergoing cardiac surgery. | — |
Countries
Brazil
Contacts
Public ContactAdriana Almeida
Hospital Nossa Senhora da Conceição
Outcome results
None listed