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Cerebral stimulation in the treatment of pain due to brachial plexus nerve damage

High-definition Transcranial Direct Current Stimulation in Treatment of Neuropathic Pain After Brachial Plexus Injury: A Randomized Pilot Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7fnwdr4
Enrollment
Unknown
Registered
2021-08-04
Start date
2021-10-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuropathic pain after brachial plexus injury

Interventions

High-definition transcranial direct current stimulation: Twenty randomly allocated participants, in the order of 1: 1, will be assigned to two stimulation groups: active (n = 10) and sham (n = 10). Th
E02.331.750

Sponsors

Programa de Pós-Graduação em Neurociência e Comportamento - Universidade Federal da Paraíba
Lead Sponsor
Laboratório de Estudos em Envelhecimento e Neurociências - Universidade Federal da Paraíba
Collaborator

Eligibility

Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 64 years; Score of 4 to 10 points on the Visual Analogue Scale (VAS); Persistent pain, refractory to clinical treatment for at least 3 months, and who have received adequate pharmacological treatment for pain with an association of antidepressants, gabapentinoid antiepileptics and analgesic opioids for at least 2 months before the start of the study.

Exclusion criteria

Exclusion criteria: Current pregnancy; Contraindications for tDCS, including metallic skull implants; Major ongoing depression, as defined by a baseline score = 29 in the Beck-II Depression Inventory (BDI-II); Previous history of alcohol or substance abuse in the last 6 months; Use of carbamazepine in the last 6 months; Previous history of epilepsy, stroke, moderate to severe head trauma, episodes of unexplained fainting or severe migraine; History of neurosurgery; Hypertrophic wounds or scars on the scalp under the placement of the electrodes.

Design outcomes

Primary

MeasureTime frame
Pain intensity improvement: for the analysis of the primary outcome, the Visual Analogue Scale will be used according to IMMPACT recommendations for clinical trials related to the treatment of chronic pain. Scores for "continuous pain" and "paroxysmal pain" will be obtained in the last 24 hours.—

Secondary

MeasureTime frame
Improvement of quality of life assessed by SF-36 Questionnaire,;Improvement of multidimensional pain descriptors assessed by the following instruments: (a) McGill Pain Questionnaire and (b) Brief Pain Inventory;Improvement of mood state assessed by the following instruments: (a) Beck Depression Inventory, (b) State-Trait Anxiety Inventory and (c) Beck Anxiety Inventory.—

Countries

Brazil

Contacts

Public ContactErickson;Suellen de Assis;Andrade

;

erickson_bonifacio@hotmail.com;suellenandrade@gmail.com+55-083-986107000;+55-083-999805189

Outcome results

None listed

Source: REBEC (via WHO ICTRP)