Systemic Arterial Hypertention
Conditions
Interventions
We will study 80 sedentary hypertensive women, divided into two large groups pre-climacteric group (30-45 years old
N = 40) and postmenopausal group (55-65 years old
N = 40). Each group will be subdivided into two smaller groups
group treated with Enalapril Maleate (N = 20) and the group treated with Losatan (N = 20). All groups will be submitted to the following experimental procedures in two moments, before and after the pe
analysis of autonomic modulation (heart rate variability, blood pressure variability and baroreflex sensitivity)
ergospirometric test
body composition (skinfolds and bioimpedance)
Other
E02.760.169.063.500.387
G11.427.410.698.277
Sponsors
Faculdade de Medicina de Ribeirão Preto
Faculdade de Medicina de Ribeirão Preto
Eligibility
Sex/Gender
Female
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: Women between 30 and 65 years of age; sedentary; with a diagnosis of systemic arterial hypertension stage I; under pharmacological treatment with Losartan or Enalapril Maleate
Exclusion criteria
Exclusion criteria: We will exclude women with cognitive disorders that impede the understanding of the tests and the aerobic physical training; with musculoskeletal disorders; endocrine diseases; metabolic diseases; cardiovascular diseases, except systemic arterial hypertension; smokers; women who use drugs that interfere with cardiac function and cardiovascular autonomic control; besides those that use hormone replacement after menopause
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate whether the association of the medication with aerobic physical training improves the cardiovascular autonomic parameters in hypertensive women both before and after menopause, analyzed by heart rate variability, blood pressure variability and baroreflex sensitivity. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected that aerobic physical training may promote an increase in oxygen consumption, evaluated in the ergospirometric test, in addition to lower values of heart rate and blood pressure at rest, when analyzed by electrocardiogram and digital sphygmomanometer, respectively.;It is possible that women present reductions in body fat percentages, skinfold analyzes and bioimpedance after aerobic physical training.;To investigate whether physical training will promote changes in concentrations of total cholesterol and fraction (LDL and HDL) analyzed by the Esterase-Oxidase method, triglycerides analyzed by the Dehydrogenase method, blood glucose analyzed by the Hexokinase-UV method, insulin analyzed by chemiluminescence, on inflammatory markers (tumor necrosis factor-alpha, interleukin 6, C-reactive protein) analyzed by chemiluminescent immunoassay method, and oxidative stress (malondialdehyde and glutathione dosage) analyzed by spectrophotometry and reading concentrations of sulfhydryl groups using a standard glutathione curve reduced. | — |
Countries
Brazil
Contacts
Public ContactHugo Souza
Faculdade de Medicina de Ribeirão Preto - FMRP/USP
Outcome results
None listed