Obesity
Conditions
Interventions
Subjects with obesity classes I or II, from both genders, aging 19 to 65 years, were included in the study and allocated into two groups: Traditional low-calorie diet (n = 17) and high protein/ low ca
Other
Sponsors
Universidade Federal de são Paulo -UNIFESP
Universidade Federal de são Paulo -UNIFESP
Eligibility
Age
19 Years to 65 Years
Inclusion criteria
Inclusion criteria: age 19 to 65 years old and obesity grade 1 and 2 (BMI 30 kg/m² to 39,9 kg/m²)
Exclusion criteria
Exclusion criteria: Patients in primary or secondary prevention of coronary artery disease with LDL-C levels greater than 190 mg / dL and triglycerides greater than 400 mg / dL; Diabetes mellitus; Untreated hypothyroidism; Liver disease; Chronic renal insufficiency; Cardiac insufficiency; Systemic infections; Failure to accept the conditions necessary to conduct the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight of the participants of the two groups evaluated in times 0, 3, 6 and 12 months;After 12 months of follow-up, a greater weight loss was observed in subjects submitted to the hyperproteic diet with restriction of carbohydrate-Dukan Diet, than those submitted to the traditional diet | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in laboratory parameters in blood samples collected at all visits, such as dosages of total cholesterol and fractions, glucose, insulin, liver enzymes, urea and creatinine, blood count. Anthropometric measures and food consumption for nutritional evaluation. Endothelial function assessed by the flow-mediated dilation of the brachial artery;At the end of the study, after 12 months of follow-up, it was observed: Improvement in some biochemical parameters in the group submitted to a hyperprotein diet with carbohydrate restriction, such as triglycerides, insulin resistance and glomerular filtration rate In the diet with carbohydrate restriction, there was a change in dietary intake of macro and micronutrients with increased protein and reduction in calories, carbohydrates, lipids, fibers, saturated fats, polyunsaturated fats, monounsaturated fats and magnesium. In the traditional diet group there was reduction only in calories, carbohydrates and vitamin B12. After 12 months, the Dukan diet was more effective than the traditional diet in reducing weight, body mass index, waist circumference, body composition with fat loss, lean mass and basal metabolic rate. At the end of the study, no significant changes no significant change was observed in the endothelial function in any group | — |
Countries
Brazil
Contacts
Public ContactFrancisco;Silvia Fonseca;Ihara
Universidade Federal de são Paulo -UNIFESP;Universidade Federal de são Paulo -UNIFESP
Outcome results
None listed