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Evaluation of the efficacy of chlorhexidine with an antidiscoloration system after third molar surgery

Clinical study of the effect of chlorhexidine with an antidiscoloration system after extraction of third molars

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7f7gf43
Enrollment
Unknown
Registered
2024-08-26
Start date
2024-06-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stained teeth

Interventions

A randomized, double-blind, crossover trial will be carried out on twenty patients who will be submited maxillary third molar extraction at the Oral and Maxillofacial Surgery II outpatient at the Fede
D02.078.370.141.100

Sponsors

Universidade Federal do Espiríto Santo
Lead Sponsor
Universidade Federal do Espiríto Santo
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Indication for extraction of the two erupted maxillary third molars; age over eighteen years; both genders; healthy; good oral hygiene; non-smokers; non-drinkers; absence of cracks in the enamel, cavities and restorations in teeth upper central incisors; color of upper incisors corresponding to at least Shade A3 on the Vita Classical shade guide

Exclusion criteria

Exclusion criteria: Pregnant women and postpartum women; chronic systemic diseases, such as uncontrolled diabetes and infectious diseases; history of hypersensitivity or allergic response to components of the mouthwash formulas under study; orthodontic treatment; periodontal disease; upper incisors stained by tetracycline or fluorosis; patients with fixed or removable dental prostheses

Design outcomes

Primary

MeasureTime frame
At the end of this research, it is expected that the addition of the Anti-Discoloration System (ADS) will reduce or eliminate tooth surface pigmentation resulting from chlorhexidine use, while maintaining antibacterial activity to control plaque and gingival inflammation post-operatively in third molar extraction surgeries. The plaque index will be assessed using the Silness and Löe test (1966). The color of teeth eleven and twenty-one will be digitally evaluated using the Vita EasyShade spectrophotometer (Vita-Zahnfabrik, Bad Säckingen, Germany), with measurements compatible with the Vita Classical shade guide (Vita-Zahnfabrik, Bad Säckingen, Germany). Color differences (final minus initial) between groups will be compared using means and standard deviations. Gingival tissue healing in the lower third molar extraction area will be evaluated based on the model proposed by Cortellini et al. (2008), assessing inflamed tissue around sutures, gingival edema, and presence of granulation tissue on a scale from zero (absent) to one (present). Saliva collection for microbiological analysis will occur at three time points: pre-surgery, on the seventh day, and on the fifteenth day of mouthwash use, to compare bacterial colony counts before and after use. Statistical analyses will be conducted using IBM SPSS Statistics version 21.

Secondary

MeasureTime frame
Secondary outcomes are not expected.

Countries

Brazil

Contacts

Public ContactIngrid Almeida

Universidade Federal do Espiríto Santo

ingridtalmeida@gmail.com+55 (82) 98130-9804

Outcome results

None listed

Source: REBEC (via WHO ICTRP)