FindTrial
Sign In

Effect of Mental Stress on vascular response in Resistant Hypertension

The role of Nitric Oxide pathway on vascular response to Mental Stress in Treatment-resistant Hypertension

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7dghjm
Enrollment
Unknown
Registered
2019-07-05
Start date
2019-07-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Essential Hypertension

Interventions

Experimental group: 30 patients with essential hypertension and resistance to treatment (15 men and 15 women) will undergo a retrograde blood flow induction maneuver (venous occlusion device) and a me
Drug
Other
E07.858.690.930
F04.711.513.703

Sponsors

Universidade Federal Fluminense
Lead Sponsor
Universidade Federal Fluminense
Collaborator

Eligibility

Age
40 Years to 65 Years

Inclusion criteria

Inclusion criteria: 40 to 65 years; diagnosis of essential hypertension; adherence to the treatment confirmed; blood pressure of at least 140 to 85 mmHg despite treatment with three anti-hypertensive drugs; blood pressure less than 130 to 85 with the use of four or more antihypertensive drugs.

Exclusion criteria

Exclusion criteria: Secondary hypertension; diabetes mellitus; stage III, IV and V chronic kidney disease; coronary artery disease; cerebrovascular disease; hepatic insufficiency; ophthalmologic disorders; regular use of nitric oxide donor drugs; stimulators of guanylate cyclase; pregnancy or lactation; current abuse of alcohol or other drugs; severe past drug allergy.

Design outcomes

Primary

MeasureTime frame
Improvement of vascular and hemostatic response to mental stress in patients with resistant hypertension; verified by decreased flow-mediated dilatation, pulse wave velocity, coagulation markers and increased bioavailability of nitric oxide; from the observation of a p value less than or equal to 0.05 in the comparisons of the pre- and post-intervention measurements.—

Secondary

MeasureTime frame
Difference in the behavior of vascular variables and hemostatic to mental stress among men and women with resistant hypertension; verified by measurements of flow-mediated dilatation, pulse wave velocity, coagulation markers, and bioavailability of nitric oxide; from the observation of a p value less than or equal to 0.05 in the comparisons of the pre- and post-intervention measurements.—

Countries

Brazil

Contacts

Public ContactNatália Rocha

Universidade Federal Fluminense

nataliagalito@id.uff.br+55 21 26292403

Outcome results

None listed

Source: REBEC (via WHO ICTRP)