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Comparison of the effects of Dexamethasone and Non-Steroidal Anti-inflammatories in the post-operative Removal of wisdom teeth

Comparison of the effects of Dexamethasone and Non-Steroidal Anti-inflammatories in the post-operative Removal of third molar extractions: randomized and triple blind clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7d4c99f
Enrollment
Unknown
Registered
2024-10-29
Start date
2023-02-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anti-Inflammatory Agents

Interventions

This study is a randomized, 3-arm, triple-blind clinical trial. 29 patients and 36 teeth were selected (taking into account that each patient could have two teeth allocated to two different groups) wh

Sponsors

Universidade Santo Amaro
Lead Sponsor
Universidade Santo Amaro
Collaborator

Eligibility

Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: They presented good systemic health conditions (ASA I); were between 18 and 35 years of age of both sexes; were indicated for extraction of the 38 and/or 48 impacted or semi-impacted dental elements, requiring a total mucoperiosteal flap and osteotomy

Exclusion criteria

Exclusion criteria: Patients who did not meet these inclusion criteria; who had any local inflammatory or infectious condition that would contraindicate tooth extraction; any type of hypersensitivity reaction to the medicinal substances that were used in the research

Design outcomes

Primary

MeasureTime frame
Expected outcome 1: It was hoped that the use of dexamethasone would promote lower or equal values to the non-steroidal anti-inflammatory drugs Ibuprofen and Ketorolac, with regard to the parameters of pain.;Outcomes found 1: As an outcome, it was observed that the ketorolac was the one that promoted the best values for the parameters of analgesia

Secondary

MeasureTime frame
Expected outcome 2: It was expected to observe that the use of dexamethasone could promote lower or equal values to the non-steroidal anti-inflammatory drugs Ibuprofen and Ketorolac, regarding the parameters edema and trismus;Outcome found 2: As a secondary outcome, it was observed that the NSAID ketorolac was the one that promoted better values for the parameters edema and trismus

Countries

Brazil

Contacts

Public ContactGustavo Momesso

Universidade Santo Amaro

gustavomomesso@gmail.com+55-11-21418555

Outcome results

None listed

Source: REBEC (via WHO ICTRP)