Use of ultrasound in disinfection during root canal treatment

Passive x Continuous Ultrasonic Irrigation in primary endodontic infections: action in the present microbiote, endotoxins and imflamatory profile

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

REBEC

Registry ID

RBR-7cxwg5

Enrollment

Unknown

Registered

2018-07-13

Start date

2017-06-12

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Pulp Necrosis

Interventions

Group 1 Number of participants: 15 Procedures performed: Conventional Irrigation - Endodontic treatment Medication: Calcium hydroxide with serum Availability: 1:1 Medication time: 14 days Method of

Procedure/surgery

E06.397.778

E06.397.778.889

H01.671.031.849

E06.397.778.778

Eligibility

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients in adulthood; Need for endodontic treatment; Permanent teeth with primary endodontic infection; Unirradicular; Presence of a single canal and periapical lesion; Absence of periodontal pockets greater than 4 mm; No mobility

Exclusion criteria

Exclusion criteria: Teeth that can not be insulated with the rubber dam; With root fracture; Exposure of the pulp chamber; Patients who have used antibiotics or antifungals in the last 3 months; Patients with systemic disease.

Design outcomes

Secondary

Measure	Time frame
Expected outcome 2- Reduction of bacterial count by colony-forming unit counts (CFU/ml), compared to values at the beginning of treatment, based on a variation of at least 5% in pre and post-intervention measurements.;Expected outcome 3 - Reduction in endotoxin levels by means of the Chromokinetic Test of Limulus Amebocyte Lysates (KQCL) compared to the initial values from the observation of a variation of at least 5% in the pre and post intervention measurements.	—

Measure

Time frame

Expected outcome 2- Reduction of bacterial count by colony-forming unit counts (CFU/ml), compared to values at the beginning of treatment, based on a variation of at least 5% in pre and post-intervention measurements.;Expected outcome 3 - Reduction in endotoxin levels by means of the Chromokinetic Test of Limulus Amebocyte Lysates (KQCL) compared to the initial values from the observation of a variation of at least 5% in the pre and post intervention measurements.

—

Primary

Measure	Time frame
Expected outcome 1 - Reduction in cytokines (IL-1alfa, IL-1beta, TNF-alfa)e MMPs (MMP-2, MMP-9) levels, verified by the enzyme-linked immunosorbent assay (ELISA) method, which allows detecting amounts of protein of the order of nanograms (10-9 g) compared to the initial values from the observation of a variation of at least 5% in the pre and post intervention measurements.	—

Countries

Brazil

Contacts

Public ContactEsteban Flores Orozco

ICT - Universidade Estadual Paulista Júlio de Mesquita Filho

esteban.flores.orozco@outlook.com+55-12-981257965

Outcome results

None listed

Source: REBEC (via WHO ICTRP)