myasthenia Gravis
Conditions
Interventions
Patients will undergo a clinical interview-type examination conducted by sleep a standard overnight polisomnography, pulmonary function, respiratory muscle strength test, test negative expiratory pres
Other
E01.370.386.700.660.225.500
Sponsors
Universidade Nove de Julho - UNINOVE
Universidade Nove de Julho - UNINOVE
Eligibility
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with Myasthenia Gravis, clinically stable, of both genders, aged between 18 and 65 years, who agree to participate in this study by signing the Instrument of Consent.
Exclusion criteria
Exclusion criteria: Patients who making use of abusive alcohol and or drugs and which is not available to participate in all stages of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea/Hypopnea index per hour of sleep (AHI) recorded by polysomnography complete, after the clinical and demographic collecting data. ;Expiratory flow limitation as flow drop (V`), expressed as the percentage of expiratory peak flow immediately after negative expiratory pressure test application. This will be measured after the clinical and demographic collecting data and after the obstruction diagnosis by spirometry is discarded. ;Volume expired in 0.2s (V0.2s) immediately after negative expiratory pressure administration. This will be measured after the clinical and demographic collecting data and after the obstruction diagnosis by spirometry is discarded. | — |
Secondary
| Measure | Time frame |
|---|---|
| High/low risk at Berlin Questionnaire which is a 10-item questionnaire with recognized efficacy in distinguishing subjects at greater risk for OSA. This will be measured after the clinical and demographic collecting data. ;Score at the Epworth Scale, which is used for the assessment of excessive daytime sleepiness. This will be measured after the clinical and demographic collecting data. ;Sleep efficiency, as assessed by the basal nocturnal polysomnography. This will be measured after the clinical and demographic collecting data, by the standard overnight polysomnography. ;Time with peripherical oxyhemoglobin saturation (SpO2 < 90%), as assessed by the basal nocturnal polysomnography. This will be measured after the clinical and demographic collecting data, by the standard overnight polysomnography. | — |
Countries
Brazil
Contacts
Public ContactLuís Oliveira
Universidade Nove de Julho - UNINOVE
Outcome results
None listed