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Effects of physical exercise on kidney function, daily living skills and quality of life in people with Chronic Kidney Disease

Chronic effects of strength training with blood flow restriction on glomerular function, functional capacity and perceived quality of life in people with Chronic Kidney Disease

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7bt6dxb
Enrollment
Unknown
Registered
2025-01-28
Start date
2024-01-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Insufficiency Chronic

Interventions

This is an unblinded randomized controlled clinical trial, with 40 volunteers. The proposed intervention protocol will be strength training associated with the blood flow restriction method. The physi
group 2 (10 adults and elderly people of both sexes with stage 3 Chronic Kidney Disease), with low-load strength training
group 3 (10 adults and elderly people of both sexes with stage 3 Chronic Kidney Disease) with high-load strength training
group 4 (10 adults and elderly people of both sexes with stage 3 Chronic Kidney Disease), without any type of strength training. The groups will be matched in terms of gender, activity level, stage 3
in the 2nd cycle (4t

Sponsors

Empresa Brasileira de Serviços Hospitalares - EBSERH
Lead Sponsor
Hospital Universitário Professor Alberto Antunes da Universidade Federal de Alagoas
Collaborator

Eligibility

Age
35 Years to 75 Years

Inclusion criteria

Inclusion criteria: volunteers with stage 3 chronic kidney disease; both sexes; aged between 35 and 75 years; without a diagnosis of Hepatitis C or B; without flu-like syndromes; without coagulation dysfunction or signs of thrombophlebitis; without severe arrhythmia, angina or cerebrovascular or cardiovascular disease; without pulmonary congestion or peripheral edema; ankle-brachial index within normal standards

Exclusion criteria

Exclusion criteria: volunteers who suffer from any hypokinetic or osteoarticular disease or cardiovascular events during the intervention; medical recommendations to leave the study; attendance of less than 85% of the sessions planned for the intervention; personal needs and wishes to withdraw from the study

Design outcomes

Primary

MeasureTime frame
We expected to find an improvement in kidney function, as assessed by blood tests, with a decrease in the variable mean creatinine of 0.30 mg/L. Data collected one week before the intervention and one week after the end of the intervention;We expected to find an improvement in kidney function, as assessed by blood tests, with a decrease in the variable mean Cystatin-C of 0.50 mg/L. Data collected one week before the intervention and one week after the end of the intervention;e expected to find an improvement in kidney function, assessed by urine tests, with a decrease in the variable mean of a decrease in microalbuminuria of 50 mg/L. Data collected one week before the intervention and one week after the end of the intervention

Secondary

MeasureTime frame
It is expected that there will be an improvement in the perception of quality of life, as assessed by the Short Form Quality of life 36 questionnaire, with an average increase of 15 points in the dimensions of the instrument. Data collected one week before the intervention and one week after the end of the intervention;It is expected to find an improvement in functional capacity levels, assessed using the physical tests proposed by Rickli & Jones, with an average increase of 3kg/f in strength tests. Data collected one week before the intervention and one week after the end of the intervention;We expect to find an improvement in functional capacity levels, assessed using the physical tests proposed by Rickli & Jones, with an average increase of 4.0 cm in the flexibility tests. Data collected one week before the intervention and one week after the end of the intervention;It is hoped to find an improvement in functional capacity levels, assessed using the physical tests proposed by Rickli & Jones, with an average increase of 100m in the walking test. Data collected one week before the intervention and one week after the end of the intervention

Countries

Brazil

Contacts

Public ContactAntonio Caetano

Universidade Federal de Alagoas

filipe.caetano@iefe.ufal.br+55 (82) 991211044

Outcome results

None listed

Source: REBEC (via WHO ICTRP)