Women under the age of 65
Conditions
Interventions
Intervention: 45 women will receive Magnesium Sulfate in a continuous infusion pump 50 mg / kg IV within 15 minutes followed by 15 mg / kg / h until the end of the surgical procedure plus Subarachnoid
Drug
E03.091
Sponsors
Hospital Geral de Cuiabá
Hospital Geral de Cuiabá
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Women under the age of 65; classified in Physical State I to III of the American Society of Anesthesiology; who are candidates for non-oncologic abdominal hysterectomy
Exclusion criteria
Exclusion criteria: Age under 18 years; body mass index less than 40; renal dysfunction; neuropathy or myopathy; known hypersensitivity to magnesium sulfate or to drugs used according to the protocol; previous treatment with calcium channel blockers; all types of heart block; opiate addiction; patient's refusal to participate in the study; contraindication to spinal anesthesia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decreased postoperative pain by at least 30% assessed using the 0-10 cm Visual Analogue Scale (VAS), where one end of the line is written “no pain” and the other “worst pain imaginable”. This assessment will be performed at rest and during the change from the supine position to the sitting position in the hospital bed at six and 24 hours after the operation. | — |
Secondary
| Measure | Time frame |
|---|---|
| The delay in administering the first analgesic rescue with tramadol, using the Kaplan-Meir curve in the first 24 hours after surgery.;Reduction in the incidence of nausea (subjective feeling unpleasant to the imminence of vomiting) and vomiting (rapid and forced expulsion of gastric contents through the mouth, caused by a strong and sustained contraction of the chest and abdominal wall muscles) in 24 hours postoperatively .;Decreased consumption of tramadol in mg to treat pain in the first 24 hours after surgery. | — |
Countries
Brazil
Contacts
Public ContactMarcio Benevides
Hospital Geral de Cuiabá
Outcome results
None listed