Osteoarthritis, Knee
Conditions
Interventions
This is a randomized, controlled, double-blind clinical study aimed at evaluating the response of pain, inflammation and functionality in women with knee osteoarthritis after application of Miconia al
Sponsors
Universidade Federal de Sergipe
Universidade Federal de Sergipe
Eligibility
Sex/Gender
Female
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: Female subjects with radiographs showing knee osteoarthritis grades II and III on the Kellgren and Lawrence osteoarthritis classification. Knee pain greater than 3 on the numerical pain rating scale. Age 50 to 70 years and functional impairment in the past 3 months that met at least one of the American College of Rheumatology classification criteria
Exclusion criteria
Exclusion criteria: Female individuals with neurological, cardiovascular and/or pulmonary diseases that may compromise the execution of the exercise protocol. Have used intra-articular injections of steroids or other substances in the last three months. Have systemic inflammatory disease. Have had orthopedic surgery on the lower limbs or are unable to perform the protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected that after application of the formulation containing Miconia albicans combined with resistance training, the participants' pain will reduce and the pressure pain threshold in the knee will increase, verified by means of the verbal numerical scale method and blood algometry, and a variation of at least 5% will be observed in the pre and post intervention measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected that after application of the formulation containing Miconia albicans combined with resistance training, the participants' inflammatory markers will be reduced, verified by means of the method of cytokine dosages in the individuals' plasma through blood collection and a variation of at least 5% will be observed in the pre and post intervention measurements.;It is expected that after application of the formulation containing Miconia albicans combined with resistance training, the participants' physical test execution time will improve, as verified by means of functional tests: 6-minute walk, Time up and go test, Sit and stand from the chair and Step up and down, and a variation of at least 5% in pre and post intervention measurements will be observed. | — |
Countries
Brazil
Contacts
Public ContactMarceli Moura
Universidade Federal de Sergipe
Outcome results
None listed