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Effect of Gum Treatment in Diabetic Patients

Impact of Periodontal Disease and the Expression of Cytokines Associated with T Helper 17 and Regulatory T Cells on the Metabolic Control of Patients with Type 2 Diabetes Mellitus

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-777nzpz
Enrollment
Unknown
Registered
2024-07-24
Start date
2022-12-30
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus

Interventions

This is a two-arm, double-blind, randomized controlled clinical study. 50 patients will be recruited from the Faculty of Dentistry of Araçatuba, Universidade Estadual Paulista "Júlio de Mesquita Filho
E06.721.189.350

Sponsors

Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho
Lead Sponsor
Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho
Collaborator

Eligibility

Age
30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients aged = 30 and =70 years; Diagnosis of periodontitis according to the classification of periodontal conditions and diseases with interproximal clinical attachment level (CAL) = 2 or CAL= 3 mm in more than 2 non-adjacent teeth (excluding the CAL limits cited in cases related to periodontitis: gingival recession of origin traumatic; dental cavities extending into the cervical area of ??the teeth; presence of CAL in the distal part of the second molar and associated with poor dental position or extraction of the third molar; endodontic lesion reaching the gingival margin and occurrence of vertical root fracture. Participants should also present at least 4 sites with probing depth (PD) =4mm with bleeding on probing (BP); present at least 15 teeth, excluding third molars and be diagnosed with type 2 diabetes mellitus (DM2) (HbA1c > 6.5% ) in the DM2 group and absence of DM2 diagnosis (HbA1c = 6.5%) in patients in group P

Exclusion criteria

Exclusion criteria: Received prior non-surgical periodontal treatment within 6 months of the study; Had used antibiotics and anti-inflammatories within three months before the start of the study; Women were pregnant or breastfeeding; Use of immunosuppressants and/or have blood disorders; Were undergoing orthodontic treatment; If they needed prophylactic antibiotic therapy

Design outcomes

Primary

MeasureTime frame
Improvement in periodontal clinical parameters such as clinical insertion level, bleeding on probing and probing depth, verified through probing depth, after intervention—

Secondary

MeasureTime frame
Improvement in glycated hemoglobin parameters—

Countries

Brazil

Contacts

Public ContactLetícia Theodoro

Faculdade de Odontologia de Araçatuba FOA

leticia.theodoro@unesp.br+55 (18) 3636-2860

Outcome results

None listed

Source: REBEC (via WHO ICTRP)