Burning Mouth Syndrome
Conditions
Interventions
This will be an open clinical trial in which we will recruit 40 women aged> 40 years with SAB referred to the Center for Diagnosis of Mouth Diseases of the UFPel School of Dentistry (CDDB) from Septem
Other
E02.190.755
Sponsors
Faculdade de Odontologia Universidade Federal de Pelotas
Faculdade de Odontologia Universidade Federal de Pelotas
Eligibility
Sex/Gender
Female
Age
40 Years to 100 Years
Inclusion criteria
Inclusion criteria: Women over 40 diagnosed with BMS by an oral medicine specialist according to the international classification of headache disorders; complaining of an intraoral burning sensation for more than 2 hours for more than three months; clinically normal oral mucosa; without signs of neuropathies involving other pathologies; without articular function; normal blood samples (red blood cell and leukocyte count, C-reactive protein levels, normal levels; no anemia); in the case of previous treatment for BMS it must have been included ineffective and discontinued for a minimum period of 2 months before being included in the study
Exclusion criteria
Exclusion criteria: Women with oral lesions or systemic diseases associated with BMS; Women in current treatment for BMS; Women with a glycated hemoglobin level (hemoglobin A1C)> 7%; pregnant women; women being treated with corticosteroids; women with lesions in the oral mucosa or patients with dental prosthesis; women with anemia, Sjoegren's Syndrome or another Autoimmune Diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relief of severity of symptomatic perception of burning mouth by at least 50% For this purpose the Scala and Fox test will be applied by means of a visual analog scale with points from 1 to 10, where 1 represents the absence of symptoms and 10 represents the maximum symptomatic perception experienced by the patient at the beginning of the test. study and after 30 and 60 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| Increased speed of unstimulated salivary flow by at least 0.3 ml / min more compared to the initial flow Samples of non-stimulated saliva will collect at the beginning of the study and after 30 and 60 days. The saliva samples will collected under resting conditions in a quiet room between 9:00 A.M. and 12:00 P.M. One hour before sample collection, the patients were asked not to smoke, brush their teeth, or eat. After 5 min of relaxation, the patients will collect saliva for 5 min in centrifuge tubes that were preweighed and labeled according to the protocol described by Navazesh. During the procedure, the patients will instructed to remain seated, quiet, and not to speak. After the procedure, the tubes containing the saliva samples will place in a container at 5°C for transportation to the laboratory of the Center for Diagnosis of Mouth Diseases (CDDB) at the Faculty of Dentistry of the Federal University of Pelotas. Each tube will later weighed by gravimetry, assigning a specific weight of 1.005 g/ml to the fluid, and the total volume will express in ml/min to determine the SFR. ;Salivary pH measurement. There is not enough evidence to estimate whether the pH will be maintained, decreased or increased. The pH of the saliva samples will determined at the beginning of the study and after 30 and 60 days using saliva from the same tube for which the SFR was measured. A digital pH meter (PL-600 EZDO-OMEGA model according to the ISO-9001 regulation) automatically will provided the pH value to two decimal ranges. Medição de pH salivar | — |
Countries
Brazil
Contacts
Public ContactJuan Aitken Saavedra
Faculdade de Odontologia Universidade Federal de Pelotas
Outcome results
None listed