Hypertension
Conditions
Interventions
This is a randomized controlled clinical trial conducted in two phases. In Phase I with a crossover design forty five adults and older adults with systemic arterial hypertension will perform five expe
Sponsors
Centro de Ciências da Saúde da Universidade Estadual de Maringá
Universidade Estadual de Maringá
Eligibility
Sex/Gender
Male
Age
40 Years to 79 Years
Inclusion criteria
Inclusion criteria: Age between 40 and 79 years; clinical diagnosis of stage I or stage II systemic arterial hypertension confirmed by ambulatory blood pressure monitoring performed within the last six months; regular use of antihypertensive medication; physical and cognitive ability to perform the exercise protocols; signed informed consent form
Exclusion criteria
Exclusion criteria: Inability or refusal to sign the informed consent form; myocardial infarction; revascularization procedures; deep vein thrombosis; stroke or pulmonary embolism in the last twelve months; chronic heart failure class III or class IV according to the new york heart association classification (nyha); unstable arrhythmia; chronic obstructive pulmonary disease requiring corticosteroid therapy or oxygen therapy; renal disease under dialysis treatment; progressive neurological disorders such as parkinson disease or multiple sclerosis; cancer under treatment in the last two years; participation lower than seventy five percent of exercise sessions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the acute effect in phase I of a single session of high intensity interval training moderate intensity continuous aerobic training resistance training combined training and control condition on central and peripheral ambulatory blood pressure measured by twenty four hour ambulatory blood pressure monitoring expecting to observe acute reductions in blood pressure values and to evaluate the chronic effect in phase II over twelve weeks of the same interventions on central and peripheral ambulatory blood pressure expecting to observe sustained reductions in systolic and diastolic blood pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate in phase I the acute effects of the interventions on arterial stiffness measured by pulse wave velocity expecting acute reductions in arterial stiffness on endothelial function measured by flow mediated dilation expecting acute increases in vascular dilation response and on cardiac mechanical function assessed by echocardiographic parameters expecting acute improvements in ventricular arterial interaction and to evaluate in phase II the chronic effects of the interventions on arterial stiffness measured by pulse wave velocity expecting sustained reductions in arterial stiffness on endothelial function measured by flow mediated dilation expecting sustained improvements in vascular dilation capacity on cardiac function and mechanics assessed by echocardiographic indices expecting improvements in cardiac performance on body composition measured by dual energy x ray absorptiometry expecting reductions in body fat and increases in lean mass and on aerobic fitness measured by cardiopulmonary exercise testing expecting increases in maximal oxygen consumption | — |
Countries
Brazil
Contacts
Public ContactGustavo De Oliveira
Universidade Estaudual de Maringá
Outcome results
None listed