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Influence of human enzyme gene variations on the effects of peppermint essential oil supplementation on physical performance of runners

Influence of the ACE gene polymorphism on the effects of peppermint (Mentha piperita L.) essential oil supplementation on the physical performance of runners

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
REBEC
Registry ID
RBR-75zt25z
Enrollment
Unknown
Registered
2022-07-30
Start date
2021-10-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise

Interventions

The product that will be ingested by the athletes in this study will be the essential oil of peppermint, extracted from an edible plant and culturally used by the population in its fresh form and in t
RAJABI, 2013
HP4.018.499.361
G07.203.300.456

Sponsors

Federal University of Paraíba
Lead Sponsor
Federal University of Paraíba
Collaborator

Eligibility

Sex/Gender
Male
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: As inclusion criteria, athletes must have at least one year of training, with a weekly frequency of five training sessions, of which at least three must be running, weekly training volume of at least 50km covered, and have been training for some competition for at least four months of uninterrupted season.

Exclusion criteria

Exclusion criteria: Will be excluded from the study volunteers who change the usual pattern of eating or exercise training during the study period, do not consume the amount of peppermint essential oil-based drink or controls provided, present gastrointestinal intolerance and do not participate in all the experimental procedures. If they have any recognized chronic-degenerative disease, be smokers and make continuous use of any medication. In addition, if you are in the habit of regularly consuming mint and its derivatives, as well as any alcoholic beverage, vitamin food supplements or those containing the active substances present in peppermint (polyphenols, flavonoids, carotenes and menthol).

Design outcomes

Primary

MeasureTime frame
It is expected to find an improvement in the time to exhaustion of runners, using the method of running to exhaustion on a treadmill. We will observe whether the recreational runner athlete will improve his time to exhaustion from the finding of a variation considered statistically significant when comparing these times in the interventions with the experimental and control drink.

Secondary

MeasureTime frame
It is expected to find a relationship between the polymorphism in the ACE gene and the physical performance of the runners, using the method of collecting a genetic sample through human saliva. We will observe whether or not the presence of this polymorphism influences the runner's physical performance in their time to exhaustion, based on a comparison between the polymorphism and the time to exhaustion of these runners in each experimental and control group;It is expected to find a relationship between the behavior of oxidative stress and muscle damage after supplementation with peppermint essential oil and control. We will use the blood collection method to measure these biochemical markers. We will observe if the oxidative stress and muscle damage of these runners change after the test until exhaustion and supplementation with peppermint essential oil and control, based on the finding of a change in these markers and if the experimental drink influenced, when compared to the control.;It is expected to find a relationship between the behavior of body temperature after supplementation with peppermint essential oil and control. We will use the method of collecting this body temperature through an ear thermometer. We will observe if this temperature of these runners changes after the test until exhaustion and supplementation with peppermint essential oil and control, from the finding of a change in this marker and if the experimental drink influenced, when compared to the control.

Countries

Brazil

Contacts

Public ContactPró-Reitoria de Pós-Graduação e Pesquisa Universidade Federal da Paraíba

Pró Reitoria de Pesquisa - PROPESQ UFPB

sec@prpg.ufpb.br+55 83 32167216

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 10, 2026