inflammation
Conditions
Interventions
Experimental group: 45 individuals with obesity BMI 40 kg/m² (regardless of the presence of comorbidities) or 35 kg/m² with comorbidities associated with obesity (Diabetes Mellitus, Systolic Arterial
E02.650.500.062.249
Sponsors
Departamento de Biociências -Baixada Santista
Universidade Federal de São Paulo
Eligibility
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Diagnosis of obesity and indication for bariatric and metabolic surgery; eutrophic participants with indication for cholecystectomy; age between 18 and 50 years; both sexes; body mass index greater than 40 kg/m² or greater than or equal to 35 kg/m² with comorbidities; body mass index between 18.5 and 24.9 kg/m² for the eutrophic control group.
Exclusion criteria
Exclusion criteria: Psychiatric disease; chronic alcoholism; history of kidney and heart disease; decompensated clinical illnesses; use of vitamin supplementation; diagnosis of obesity due to genetic diseases; individuals with walking disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the inflammatory index of the diet, using the method of calculation of the inflammatory index of the diet, with a positive score for a pro-inflammatory diet and a negative score for an anti-inflammatory diet in the measurements before and after surgical intervention, it is expected to find tissue changes visceral adipose tissue, using the histopathology method, observing the presence/absence of pro-inflammatory cells in the tissue before and after surgical intervention and evaluating metabolic and inflammatory changes through the laboratory method of analysis by enzyme-linked immunosorbent assay (ELISA) and method enzymatic colorimetric comparison, based on the finding of a variation of at least 5% in pre- and post-intervention measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to find that the inflammatory index of the diet, verified by the method of calculating the inflammatory index of the diet, with a positive score for a pro-inflammatory diet and a negative score for an anti-inflammatory diet in measurements before and after surgical intervention; industrial food processing, verified by the NOVA food method, observed by the largest number of ultra-processed foods and ingredients, and the quality of the diet, verified by the diet quality index method, observed by the score 70 points for a good quality diet, correlates with the lipid profile and glucose metabolism, evaluated by the enzymatic colorimetric comparative method, based on the finding of a variation in at least 5% in pre-and post-intervention measurements.;Evaluate possible associations of the inflammatory profile of the diet, verified by the method of calculating the inflammatory index of the diet, with a positive score for a pro-inflammatory diet and a negative score for an anti-inflammatory diet in measurements before and after surgical intervention; with the histopathological changes of the visceral adipose tissue, using the histopathology method, observing the presence/absence of pro-inflammatory cells in the tissue before and after the intervention and evaluating changes in the biochemical markers of inflammation through the laboratory method of analysis by assay of enzyme immunoabsorption (ELISA) and body composition variables, verified by anthropometric methods from the finding of a variation of at least 5% in pre-and post-intervention measurements. | — |
Countries
Brazil
Contacts
Public ContactRaquel Mônico
Outcome results
None listed