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Comparison of the use of Mannitol vs Albumin in preventing the fall in Blood Pressure in patients with renal problems undergoing Prolonged Hemodialysis: a randomized controlled clinical trial

Evaluation of the use of Mannitol and Albumin in the prevention of intradialytic hypotension in patients with Acute Kidney Injury undergoing Prolonged Hemodialysis: a randomized clinical trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
REBEC
Registry ID
RBR-749vzfz
Enrollment
120
Registered
2026-03-12
Start date
2025-04-01
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute renal injury Sepsis

Interventions

This is a prospective, randomized clinical trial that will evaluate the prevention of hypotension during hemodialysis sessions in patients with acute kidney injury associated with sepsis. An estimated

Sponsors

Departamento de Suporte às Unidades de Saúde
Lead Sponsor
Faculdade de Medicina de Botucatu
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients admitted to the Intensive Care Units (ICU) of the Hospital das Clínicas of the Faculty of Medicine of Botucatu; over 18 years of age; with Acute Kidney Injury associated with sepsis; in acute renal support therapy undergoing Hemodialysis; using norepinephrine at a dose of 0.2 to 0.6 ucg/kg/min and being monitored by the Acute Kidney Injury group of the nephrology service

Exclusion criteria

Exclusion criteria: Patients undergoing chronic renal replacement therapy (Chronic Kidney Disease dialysis and kidney transplant) and treated with less than two prolonged hemodialysis sessions will be excluded from the study

Design outcomes

Primary

MeasureTime frame
It is expected to reduce episodes of intradialytic hypotension through the solutions used at the beginning of the session in order to assess whether any of them has a better benefit for the participant to be able to complete the 6-hour therapy in full

Secondary

MeasureTime frame
Using the method we hope to carry out the therapy for the prescribed time, as this is sometimes not possible due to hypotension. In this way, the participant improves their clinical condition, managing to achieve metabolic and volume control through hemodialysis

Countries

BR

Contacts

Public ContactMarci Maira Lunardi

Hospital das Clínicas da Faculdade de Medicina de Botucatu

marci_maira@hotmail.com+55(14)991957354

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Apr 4, 2026