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Acute effect of inspiratory muscle training on inflammation and heart function in patients with obstructive sleep apnea

Acute effect of inspiratory muscle training on inflammatory markers, cardiac autonomic activity and cardiovascular variables in patients with obstructive sleep apnea: a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-74497t
Enrollment
Unknown
Registered
2020-03-23
Start date
2019-03-20
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea

Interventions

Patients with obstructive sleep apnea will be recruited. The intervention group (20 participants) will perform inspiratory muscle training using the powerbreathe®classiclight, a device capable of prov
Device
E02.190.525.186

Sponsors

Universidade Federal de Pernambuco
Lead Sponsor
Hospital Otávio de Freitas
Collaborator

Eligibility

Age
30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Individuals of both sexes diagnosed with moderate or severe obstructive sleep apnea by polysomnography or polygraphy; be between 30 and 70 years old; no history of specific apnea treatment in the last two months; sedentary or insufficiently active according to the International Physical Activity Questionnaire

Exclusion criteria

Exclusion criteria: History of neuromuscular disorders; infectious diseases; immunological diseases; tumors; peripheral vascular diseases; coagulation disorders; liver or kidney disease; severe psychogenic disorders or acute or chronic renal failure; platelet patients; hx of head or neck injury or surgery in the last 3 months; administration of hormones, immunosuppressants, cytotoxins or free radical scavengers; use of medications such as oral corticosteroids, central nervous system depressants, barbiturates and / or muscle relaxants, patients with impaired cognitive impairing the understanding and execution of research procedures

Design outcomes

Primary

MeasureTime frame
To evaluate inflammatory response through blood markers before inspiratory muscle training immediately after and one hour after, based on a variation of at least 5%

Secondary

MeasureTime frame
To evaluate sympathetic nervous system hyperactivity and cardiac autonomic activity through heart rate variability based on a variation of at least 5%.

Countries

Brazil

Contacts

Public ContactSílvia Ferreira

Universidade Federal de Pernambuco

silviathamilis1@gmail.com+55-081-21268000

Outcome results

None listed

Source: REBEC (via WHO ICTRP)