Rubinstein-Taybi Syndrome
Conditions
Interventions
Uncontrolled study with blinded evaluator. 15 children with Rubinstein-Taybi syndrome. Ten sessions of anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex (1mA)
E02.331.750
Sponsors
Irmandade da Santa Casa de Misericórdia de São Paulo
Centro de Neuroestimulação Pediátrica
Eligibility
Age
3 Years to 6 Years
Inclusion criteria
Inclusion criteria: Children with Rubinstein-Taybi Syndrome; no brain injuries; age between three and six years; degree of collaboration compatible with adequate performance in the activities proposed in this project; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant
Exclusion criteria
Exclusion criteria: Neurological or neuromuscular diseases associated with Rubinstein-Taybi Syndrome; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find a reduction in neuropsychomotor development delay, assessed by the Bayley Scales of Infant and Toddler Development III, demonstrated by a 5% increase in the score of language items after the intervention. Data collected one week before the intervention and one and twelve weeks after the intervention;It is expected to find an increase in functional performance with increased independence in daily activities, demonstrated by an increase of 5 points in the Pediatric Evaluation of Disability Inventor after the interventions. Data collected one week before the intervention and one and twelve weeks after the intervention;It is expected to find an increase in participation, assessed by the Participation and Environment Measure for Children and Youth demonstrated by a 5% increase in scores after the interventions. Data collected one week before the intervention and one and twelve weeks after the intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects assessed using a standardized questionnaire that quantifies the perception and intensity of symptoms. Assessments performed before and after each of the ten intervention sessions. It is expected not to find moderate or severe adverse effects during the intervention period. | — |
Countries
Brazil
Contacts
Public ContactVeronica Unzueta
Faculdade de Ciências Médicas da Santa Casa de São Paulo
Outcome results
None listed