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Effects of cerebral stimulation during treadmill training on gait in people with Parkinson's disease

Effects of transcranial direct current stimulation combined with treadmill training on gait in people with Parkinson's disease: a randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-738zkp7
Enrollment
Unknown
Registered
2022-07-04
Start date
2022-09-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Interventions

Forty patients with Parkinson's disease (PD) will participate this crossover study (one arm). There will be 4 days of intervention, consisting of transcranial direct current stimulation (tDCS) and aer
in the prefrontal cortex (PFC)
in both areas simultaneously and one session will be a sham/placebo. In all sessions, anode electrodes will be positioned on M1 and PFC of the cerebral hemisphere most affected by PD. The cathode elec
E02.331.750
E02.760.169.063.500.387.250

Sponsors

Universidade Estadual Paulista, Instituto de Biociências, campus de Rio Claro
Lead Sponsor
Universidade Estadual Paulista, Instituto de Biociências, campus de Rio Claro
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Subjects with diagnosis of idiopathic Parkinson's disease given by a private neurologist, according to the London Brain Bank criteria.

Exclusion criteria

Exclusion criteria: Subjects with another neurological disease in addition to Parkinson's disease; subjects in stage above of 3 on the adapted Hoehn & Yahr scale; subjects with characteristics that make transcranial direct current stimulation risky (neural implants, history of seizures, pacemaker, epilepsy); history of orthopedic and/or vision problems that make it impossible to comply with experimental procedures; indicative of dementia.

Design outcomes

Primary

MeasureTime frame
It is expected to find improvement in walking, verified by means of an accelerometer positioned on the fifth lumbar vertebra, from the observation of the increase in walking speed in the post-intervention moments.—

Secondary

MeasureTime frame
It is expected to find a decrease in the activity of the prefrontal cortex during walking, verified by the functional near-infrared spectroscopy, from the observation of the reduction in the concentration of oxyhemoglobin in the post-intervention moments.—

Countries

Brazil

Contacts

Public ContactGabriel Antonio Moraca

Universidade Estadual Paulista, Instituto de Biociências, campus de Rio Claro

gabrielmoraca@hotmail.com+55-19-35264365

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 6, 2026