Myocardial Infarction
Conditions
Interventions
Randomized, placebo-controlled, triple-blind clinical trial to be conducted at the Hospital Evangélico Sr. e Sra. Goldsby King, Dourados, MS. The study sample will consist of adults and elderly indivi
M1 - intermediate moment, 30 days after supplementation
M2 - final moment, 90 days after supplementation. The supplements and placebo will be pre-packaged in opaque sachets/bottles and sealed by the supplier and coded only with random numbers corresponding
G07.203.300.456.500
G07.203.300.456
Sponsors
Faculdade de Ciências da Saúde da Universidade Federal da Grande Dourados
Universidade Federal da Grande Dourados - UFGD
Eligibility
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: Volunteers aged 20 or over; both sexes; undergoing Myocardial Revascularization for Atherothrombotic Coronary Artery Disease
Exclusion criteria
Exclusion criteria: Previous gastrointestinal diseases; Chronic kidney disease on dialysis; food intolerances or food allergies; alcohol or illicit drug addiction; current or previous use (up to three months) of antibiotics, laxatives and appetite suppressants; regular use of antispasmodics or antacids; current or previous use (up to three months) of dietary fiber modules, prebiotics, probiotics, synbiotics or products enriched with these ingredients; present intolerance to prebiotics, probiotics, synbiotics; pregnant or lactating women; current follow up of unusual diets (vegetarian, paleolithic, gluten free, lactose free, macrobiotic); indigenous people
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in C-reactive protein concentrations, verified by laboratory determination of this marker in blood plasma before (baseline) and after 90 days of supplementation (final). The average C-reactive protein concentrations in the intervention group will be compared with the control group | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical tests related to lipid profile and glycemic homeostasis (total cholesterol, LDL-c, HDL-c, triglycerides, fasting blood glucose), inflammation (C-reactive protein, cytokines, lipopolysaccharides), anthropometric indicators (adductor pollicis muscle thickness, body mass index, skinfolds, body circumferences and related indices), muscle stregth, gastrointestinal symptoms, and symptoms of depression and anxiety | — |
Countries
Brazil
Contacts
Public ContactRicardo Fernandes
Universidade Federal da Grande Dourados - UFGD
Outcome results
None listed