Effect of Prior Administration of the drug Ibuprofen-Arginine on the success of Anesthetic Block for Root Canal Treatment of posterior lower teeth with Symptomatic Pulpitis

Effect of Preemptive Administration of Ibuprofene-Arginine on Anesthetic Block of the inferior alveolar nerve for Endodontic Treatment of teeth with Symptomatic Pulpitis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

REBEC

Registry ID

RBR-6z4jrs8

Enrollment

Unknown

Registered

2023-07-07

Start date

2022-03-01

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulpitis

Interventions

A prospective, randomized, double-blind, placebo-controlled study is proposed. A total of 150 patients with a diagnosis of symptomatic pulpitis in lower posterior teeth will be selected. They will be

Group 2. Patients who will receive orally a single dose of 1155mg of ibuprofen arginine

Group 3. Patients who will receive a single oral dose of a placebo (Control). The patients will then receive local anesthesia by the direct technique of posterior alveolar nerve block. Endodontic trea

D12.125.068.050

D02.241.223.701.430

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Be in good health; Be in the age group over 18 years; Present a clinical diagnosis of symptomatic pulpitis in posterior lower teeth; Ability to understand the pain assessment scale

Exclusion criteria

Exclusion criteria: Under 18 years old; pregnant women; Patients who have a previous sensitivity, allergy or who cannot take ibuprofen for any other reason; Patients allergic to local anesthetics or sulfites; Patients who have an important history of health problems; Patients unable to give informed consent; Patients who have ingested analgesics or anti-inflammatory drugs in the last 8 hours prior to treatment

Design outcomes

Primary

Measure	Time frame
Expected outcome 1: Increased efficacy of anesthetic blockade of the inferior alveolar nerve, verified upon previous administration of arginine ibuprofen for endodontic treatment in patients with symptomatic pulpitis.;Outcome found 1: In the present investigation, preemptive medication with ibuprofen-arginine provided a rate of 78.0% of efficient blockade of the inferior alveolar nerve and of 62.0% when conventional ibuprofen was used. Despite the results of the ibuprofen-arginine association showing higher values, there was no statistical difference between the two groups in terms of blockade efficiency.	—

Measure

Time frame

Expected outcome 1: Increased efficacy of anesthetic blockade of the inferior alveolar nerve, verified upon previous administration of arginine ibuprofen for endodontic treatment in patients with symptomatic pulpitis.;Outcome found 1: In the present investigation, preemptive medication with ibuprofen-arginine provided a rate of 78.0% of efficient blockade of the inferior alveolar nerve and of 62.0% when conventional ibuprofen was used. Despite the results of the ibuprofen-arginine association showing higher values, there was no statistical difference between the two groups in terms of blockade efficiency.

—

Secondary

Measure	Time frame
Secondary outcomes are not expected	—

Countries

Brazil

Contacts

Public ContactJéssica Oliveira

Faculdade de Odontologia da Universidade Federal de Goiás

jessicapetini@ufg.br+55 (62)3209-6051

Outcome results

None listed

Source: REBEC (via WHO ICTRP)