Obsessive-compulsive disorder
Conditions
Interventions
Fifty patients with obsessive-compulsive disorder will be randomized to receive one single session of transcranial direct current stimulation (1-2 mAs) on the supplementary motor area for 20 minutes (
Device
Sponsors
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
Eligibility
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Fifty patients with a diagnosis of obsessive-compulsive disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); aged between 18 and 50 years; with at least primary school; able to use computers; under regular pharmacological treatment for at least 3 months.
Exclusion criteria
Exclusion criteria: Any condition that hinders the smooth progress of the procedure as psychiatric comorbidities that impedes the assessment with the dotprobe task or with symptom severity scales; cardiac pacemakers and some brands of cerebral aneurysm clips; cochlear implants and neurostimulators; firearm projectiles and other metal fragments depending on the location in the body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main primary endpoint: reduction of attentional bias of patients with obsessive-compulsive disorder submitted to transcranial direct current stimulation. The Dot Probe Task will be used to verify the reduction of attentional bias. To determine the expected outcome, a statistically significant change on the average reaction time in milliseconds to stimuli related to obsessive-compulsive disorder presented in the dot-probe task before vs. after stimulation transcranial direct current will be used. Additional primary endpoint: reduction in the severity of obsessive-compulsive symptoms. To verify the reduction of obsessive-compulsive symptoms, the Yale-Brown Obsessive-Compulsive Challenge Scale will be used. To determine the expected outcome, a statistically significant decrease in the scores of Yale-Brown Obsessive-Compulsive Challenge scale after stimulation transcranial direct current will be used. | — |
Secondary
| Measure | Time frame |
|---|---|
| Main secondary endpoint: Reduction of obsessive-compulsive symptoms as categorical variable. To verify the status of response to treatment, the Yale-Brown obsessive compulsive challenge scale will be used. To determine the expected outcome, a decrease of at least 25% of the initial scores of the Yale-Brown obsessive -compulsive challenge after transcranial direct current stimulation will be used. Additional secondary endpoint: Reduction of negative affect. To verify the reduction of negative affect, the scale of positive and negative affects will be used. To determine the expected outcome, statistically significant decreases in negative subscores of the positive and negative affect scale after transcranial direct current stimulation will be used. | — |
Countries
Brazil
Contacts
Public ContactLeonardo Fontenelle
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
Outcome results
None listed