Respiratory Distress Syndrome, Newborn
Conditions
Interventions
This is a randomized, crossover, double-blind clinical trial. The proposal, those responsible for the preparation requests, were informed about the research procedures and, later, the Free and Informe
Sponsors
Universidade Federal do Rio Grande do Norte
Universidade Federal do Rio Grande do Norte
Eligibility
Age
No minimum to 32 Weeks
Inclusion criteria
Inclusion criteria: Premature newborns (gestational age equal to or less than 32 weeks), diagnosed with Respiratory Distress Syndrome and birth weight of up to 1,500g, intubated and in a weaning protocol. The protocol maintained an inspired fraction of oxygen lower than 50%, mandatory respiratory rate lower than 30 cycles per minute, peak pressure equal to or lower than 25cmH2O, and end expiratory pressure lower than or equal to 6 centimeters of water.
Exclusion criteria
Exclusion criteria: Using medications with side effects on the respiratory system were not included and those preterm newborns who presented clinical worsening and/or need to increase ventilatory parameters were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected Outcome 1: It is expected to identify which ventilation modality promotes improvement in chest expansion and allows greater synchrony between the patient and the ventilator. ;Outcome 1: It was possible to identify an increase in chest expansion in guaranteed volume mode, indicating a better modality for weaning from ventilation in this population. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected Outcome 2: It is expected to evaluate the degree of respiratory distress in the two ventilation modes, in order to identify which of the modes promotes greater comfort for the patient. ;Outcome 2: It was possible to observe a lower degree of respiratory discomfort in NBs ventilated at a guaranteed volume through the Silverman-Andersen bulletin.;Expected Outcome 3: It is expected to identify which ventilatory modality offers the least impact on the autonomic variables in the evaluated newborns.;Outcome 3: The guaranteed volume mode was associated with a lower heart rate in newborns under mechanical ventilation. | — |
Countries
Brazil
Contacts
Public ContactPedro Ykaro Silva
Universidade Federal do Rio Grande do Norte
Outcome results
None listed