Acute renal failure
Conditions
Interventions
Control Group: 152 patients who will undergoing revascularization myocardical surgery used for volume replacement during the surgery and for the preparation of the prime and cardioplegia solutions of
Drug
Sponsors
Fundação Universitária de Cardiologia
Fundação Universitária de Cardiologia
Eligibility
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients submitted to surgical myocardial revascularization with CPB, elective and primary, with age ranging between 50 and 75 years old and both sexes
Exclusion criteria
Exclusion criteria: Preoperative: Urgency or emergency surgery, INR higher 1,3, when are lower than 100.000, altered KTTP in the absence of heparine use, use of antiplatelet agents except acetylsalicylic acid, renal insufficiency and or creatinine higher 2, hepatic insufficiency and or GOT e GPT levels more than two times the normal value, previous coagulopathy, pregnancy, breast-feeding, serum potassium higher 5.5 during preoperative period. Diagnosed diseases Von Willebrand, hemophilia, sepsis, hepatic cirrhosis and seizures Transoperative CPB duration higher than 160 minutes and realization of profound hypothermia with circulatory arrest
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| renal failure in the postoperative period, through the measurements of creatinine and urinary output within 48 hours after the surgical procedure, the criteria of the Acute Kidney Injure Network (AKIN), which proposes classification in three stages Stage 1: Increased serum creatinine by more than 0.3 mg / dl or 150-200% of baseline, or urine output less than 0.5 ml / kg / min for more than 6 hours Stage 2: Increased serum creatinine by 200 to 300% of baseline, or urine output less than 0.5 ml / kg / min for more than 12 hours Stage 3: Increased creatinine by more than 300% of the baseline, or urine output less than 0.3 ml / kg / min for 24 hours, or anuria for 12 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the time of time of hospitalization in the postoperative unit of time of mechanical ventilation ;Observation of adverse reactions of the solutions, such as metabolic acidosis and hyperlactatemia, observed through alteration of laboratory values by pH, HCO3 bicarbonate, BE base excess, potassium, sodium, lactate, hemoglobin and hematocrit measurements, according to values during and after the surgical procedure until the patient leaves the postoperative unit;Observation of differences in postoperative bleeding in the 48-hour period, reoperations and mortality during hospital stay | — |
Countries
Brazil
Contacts
Public ContactJéssica Thais de Oliveira
Fundação Universitária de Cardiologia
Outcome results
None listed