Coronavirus Infections
Conditions
Interventions
Experimental group: 80 patients recovered from COVID 19 will undergo a cardiopulmonary exercise test on a cycle ergometer (ramp protocol) to assess cardiorespiratory capacity, and the electrical activ
Dietary supplement
Other
E01.370.405.255
Sponsors
LETFAS-UFPB
LETFAS-UFPB
Eligibility
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: Patients recovered from Covid-19 with mild to severe severity (recovery within 30 days) and people not contaminated by the coronavirus; both sexes; non smokers; 18 years old or older
Exclusion criteria
Exclusion criteria: Smoking volunteers; pregnancy; morbid obesity; diagnoses of cardiac, pulmonary, hematological, neurological or neuromuscular diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presentation of the expected outcome: To assess the maximum oxygen uptake [VO2max] in patients recovered from COVID 19 and healthy individuals. Patients recovered from COVID 19, with severe severity, are expected to have lower VO2max compared to patients recovered from COVID 19 who had mild symptoms or with healthy individuals (not infected by the coronavirus). VO2max will be obtained in the cardiopulmonary exercise test [CPET], using the ramp protocol on a cycle ergometer. VO2max will be presented in absolute values (L min) and in% predicted values.;Presentation of the expected outcome: To assess neuromuscular efficiency [relationship between workload variation with the percentage of muscle activation] in patients recovered from COVID 19 and healthy individuals. Patients recovered from COVID 19, with severe symptoms, are expected to have lower neuromuscular efficiency compared to patients recovered from COVID 19, who had mild symptoms or with healthy individuals (not infected by coronavirus). The variation of workloads will be evaluated during the cardiopulmonary exercise test [25, 50, 75 and 100 watts] The percentage of muscle activation will be obtained by surface electromyography of the vastus lateralis muscle and will be presented in %RMS. | — |
Secondary
| Measure | Time frame |
|---|---|
| Presentation of the expected outcome: Assess the oxygen pulse in patients recovered from COVID 19 and healthy individuals. It is expected that patients recovered from COVID 19, with severe severity, will have a lower oxygen pulse compared with patients recovered from COVID 19, who had mild symptoms or with healthy individuals (they were not contaminated by the coronavirus). The oxygen Pulse will be obtained in the cardiopulmonary exercise test, using the ramp protocol on an exercise bike. This variable will be presented in mL/ heart rate.;Presentation of the expected outcome: To assess ventilation in patients recovered from COVID 19 and healthy individuals. It is expected that patients recovered from COVID 19, with severe symptoms will have less ventilation compared to patients recovered from COVID 19, who had mild symptoms or with healthy individuals (they were not contaminated by the coronavirus). Ventilation will be achieved by spirometry during the cardiopulmonary exercise test, using the ramp protocol on a cycle ergometer. This variable will be measured in L min.;Presentation of the expected outcome: To evaluate the ventilatory equivalent [variation between ventilation with carbon dioxide - VE / CO2 slope] in patients recovered from COVID 19 and healthy individuals. It is expected that patients recovered from COVID 19, with severe symptoms, will have a lower ventilatory equivalent when compared to patients recovered from COVID 19, who had mild symptoms or with healthy individuals (they were not contaminated by the coronavirus). The ventilatory equivalent will be obtained by spirometry during the cardiopulmonary exercise test, using the ramp protocol on a cycle ergometer. This variable will be measured in L / min. | — |
Countries
Brazil
Contacts
Public ContactAmilton;Maria do Socorro Santos;Brasileiro-Santos
LETFAS-UFPB;LETFAS-UFPB
Outcome results
None listed