Inhaled anaesthetics
Conditions
Interventions
Randomized clinical trial, blinded. Experimental group: Group 1: 45 patients submitted to total intravenous general anesthesia with propofol. Group 2: 45 patients undergoing general inhalational anest
Sponsors
Hospital Universitário Gaffree e Guinle
Hospital Universitário Gaffree e Guinle
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age above18 years; both sexes; signing of the Free and Informed Consent Form about participation in the study; physical status ASA (American Society of Anesthesia) I; II and III ( one, two and three); patients undergoing general anesthesia for laparoscopic cholecystectomy and/or thyroidectomy; lasting less than 300 minutes;
Exclusion criteria
Exclusion criteria: ASA(American Society of Anesthesia) scale four; presence of neurological or psychiatric disease affecting cognition; continuous use of: corticosteroids; antipsychotics; opioids, zolpiden; tricyclic antidepressants; smoking; alcoholism; severe liver disease; renal failure (creatinine clearance under 100); inability to perform neuropsychometric tests independentes. The following perioperative situations exclude research participants: Postoperative delirium; report of anesthetic complications, including hypoxemia; hypotension and deep anesthetic plane (BIS (Bispectral Index Scale) under thirty five); report of general anesthesia up to one year prior to surgery; previous cardiac or neurological surgeries; urgent surgeries or with intraoperative surgical complications (bleeding and reoperation)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess postoperative cognitive dysfunction (POCD) in relation to the choice of anesthetic technique in medium-sized surgeries.Through neuropsychological assessment with the Computerized Attention Test. In this test, we can measure the following variables: 1. Reaction time, 2. Reaction time variability, 3. Omission errors and 4. Commission errors. There are 4 independent variables, evaluated in the same test, where the alteration of any one of them shows attentional alteration. The analysis of the results is performed by comparing the individual's results with the standardization sample in the test manual paired by sex and age, with a difference of 1.5 standard deviation between the groups. The parameters that may be altered are:Intrinsic alert; Ability to focus and sustain attention; Inhibition of inadequate responses in the postoperative period. | — |
Secondary
| Measure | Time frame |
|---|---|
| Aplication of other tests that prove the change in cognition related to anesthesia, such as:COWAT (Controlled oral word association test); Minimental, symbol digit modality test; MoCa (Montreal Cognition Test).Comparing preoperative tests with those performed at 24h, 7 days and 30 days after surgery. | — |
Countries
Brazil
Contacts
Public ContactCarolina Mello
Hospital Universitário Gafree e Guinle
Outcome results
None listed