Effect and safety of using Pregabalin to reduce Pain after Hemorrhoid Surgery

Efficacy and safety of perioperative use of Pregabalin in reducing Pain and Rectal Tenesmus after Hemorrhoidectomy: a randomized double-blind clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

REBEC

Registry ID

RBR-6vp3srs

Enrollment

Unknown

Registered

2025-09-01

Start date

2025-05-05

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain

Interventions

This is a randomized, double-blind, placebo-controlled, parallel-group clinical trial. A total of 30 (thirty) patients over 18 years of age with grade III or IV hemorrhoidal disease will be randomly i

D12.125.190.350.450

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years old; internal hemorrhoidal disease grades III and IV; preoperative hemorrhoidectomy at Hospital Carlos Macieira

Exclusion criteria

Exclusion criteria: Patients with a history of allergy to Pregabalin; who cannot adequately answer the questionnaire

Design outcomes

Primary

Measure	Time frame
To evaluate the effect of pregabalin in reducing pain in the period of up to 14 days after open hemorrhoidectomy, compared with a placebo group, using the visual analog pain scale, with results with a p-value <0.05 in the t-test being considered relevant	—

Secondary

Measure	Time frame
Observe for possible adverse effects that may limit the use of pregabalin in the perioperative period of hemorrhoidectomy	—

Countries

Brazil

Contacts

Public ContactBruno Pereira

Universidade Federal do Maranhão

bruno.hspereira@gmail.com+5598984338796

Outcome results

None listed

Source: REBEC (via WHO ICTRP)