Clobetasol
Conditions
Interventions
This is a proof-of-concept, open-label, single-arm clinical trial with intervention through the use of topical clobetasol 0.05% on the scalp for 120 days. A total of 41 patients, between 18 and 70 yea
Sponsors
Departamento de Patologia da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista
Faculdade de Medicina de Botucatu da Universidade Estadual Paulista "
Júlio de Mesquita Filho"
- FMB/UNESP
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Sign the Free and Informed Consent Form; female; minimum age of 18 years and maximum of 70 years; clinical and trichoscopic diagnosis of Female Pattern Alopecia; Sinclair Scale from II to IV; absence of treatment for Female Pattern Alopecia for more than four months
Exclusion criteria
Exclusion criteria: Specific treatment for female pattern alopecia in the last four months; male; other associated trichological condition that may interfere with the clinical and trichoscopic analysis; hypersensitivity or allergy to any of the substances under study; use of any systemic or topical immunosuppressive substance; use of any topical or oral androgen; severe hair loss that began less than 2 months ago; immunocompromised individuals; coagulation disorders; suspected or confirmed pregnancy; women in the lactation phase
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in hair density, assessed by trichoscopy, after 120 days of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical improvement, assessed through photographic evaluation; histopathological improvement, assessed through the assessment of the presence and quantification of perifollicular inflammatory infiltrate, the vellus:terminal hair ratio and the follicular unit count in the biopsy evaluated | — |
Countries
Brazil
Contacts
Public ContactStéfany Santos
Faculdade de Medicina de Botucatu da Universidade Estadual Paulista "Júlio de Mesquita Filho" - FMB/UNESP
Outcome results
None listed