Depressive episode unspecified, Bipolar affective disorder unspecified
Conditions
Interventions
Open and controlled clinical trial involving 60 participants, 30 of whom were active and 30 of the control group to evaluate the adjuvant effect of ketamine. Participants will start with a dose of 0.4
Drug
Sponsors
Hospital São José
Hospital São José
Eligibility
Inclusion criteria
Inclusion criteria: Volunteers who have some mood disorder and high risk of suicide; age from 14 to 74 years of age
Exclusion criteria
Exclusion criteria: Volunteers manifesting delusions or manic symptoms upon examination of mental state or by BPRS and / or YOUNG; present substance use disorder with recent use in the last 72 hours (except nicotine and benzodiazepines) or present severe exogenous intoxication; being pregnant or with suspected pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of the depressive symptoms during the intervention period (maximum of 14 days) verified by the Montgomery Asberg Depression Rating Scale (MADRS) from the observation of the reduction of at least 50% in the pre and post intervention measurements | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission of suicidal ideation during the intervention period (maximum of 14 days) verified through item 10 of the MADRS instrument from the observation of the total remission (zero value) in the post-intervention measurement, using the pre-intervention measurement as the baseline | — |
Countries
Brazil
Contacts
Public ContactRafael de Araújo
Hospital São José
Outcome results
None listed