Nasal Polyps Rhinosinusitis
Conditions
Interventions
This is a single-arm prospective clinical study involving 30 participants diagnosed with chronic rhinosinusitis with nasal polyps, without a control group or randomization. The histopathological analy
Sponsors
Universidade Federal de Pernambuco - UFPE
Universidade Federal de Pernambuco - UFPE
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: individuals over 18 years of age; diagnostic criteria for chronic rhinosinusitis with nasal polyps; voluntary participation confirmed by signing the informed consent form
Exclusion criteria
Exclusion criteria: absence of visible polypoid disease on nasal endoscopy; sinonasal neoplasms or secondary causes of chronic rhinosinusitis; comorbidities contraindicating the use of systemic corticosteroids, even for a short period; chronic use of corticosteroids or immunodeficiencies; history of head and neck radiotherapy or previous nasal trauma; pregnancy; psychiatric disorders without clinical control
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variation in tissue eosinophil count per high power field in nasal polyp samples comparing baseline values and after a seven day course of prednisolone forty milligrams per day in patients with chronic rhinosinusitis with nasal polyps with individualized analysis of the nasal cavities | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include the variation in the Sino Nasal Outcome Test scores and the Visual Analogue Scale scores for nasal obstruction and rhinorrhea and smell and facial pain and sleep quality and the Lund Kennedy endoscopic staging score and the results of the olfactometry using the MultiScent 20 Health system and the variation in serum eosinophilia levels | — |
Countries
BR
Contacts
Public ContactCamila Muniz
Universidade Federal de Pernambuco - UFPE
Outcome results
None listed