Fungal Keratitis
Conditions
Interventions
Antifungal intracameral injection (voriconazole 50MCG/0,1ML and amphotericin B 5MCG/0,1ML), every 72 hours, until improvement or at most 5 injections. Ten patients will be recruited in each group (vor
Drug
C11.204.564
Sponsors
Departamento de Oftalmologia Universidade Federal de São Paulo
Departamento de Oftalmologia da Universidade Federal de Uberlândia
Fundação Banco de Olhos de Goiás
Eligibility
Inclusion criteria
Inclusion criteria: Patients with suspected fungal keratitis, with positive or ongoing culture, who do not show clinical improvement after 10 days of topical antifungal treatment or with anterior chamber involvement
Exclusion criteria
Exclusion criteria: Age under 12 years, affection limited to the anterior third of the corneal stroma; presence of corneal perforation, atalamy or scleral involvement; patients or guardians who do not agree to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Therapeutic corneal transplantation. After using the studied therapy (randomized medication), corneal transplantation will be indicated as rescue therapy for patients who present refractory symptoms, with no response to the medication administered. Clinical refractoriness will be considered as: absence of biomicroscopic improvement of the fungal keratitis after 5 therapeutic injections, perforation or imminence of corneal perforation and scleral involvement. Patients will be clinically assessed by slit lamp examination before randomization and at pre-specified times after the therapy studied. The transplant indication rate (%) will be calculated in each group for comparison | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected | — |
Countries
Brazil
Contacts
Public ContactFernanda Bezerra Linhares
Departamento de Oftalmologia Universidade Federal de São Paulo
Outcome results
None listed