Cognition
Conditions
Interventions
The study will be conducted in three phases. In the first phase, participants will complete an electronic registration form and online questionnaires covering seven domains of brain health (general he
Sponsors
União Brasileira de Educação e Assistência
União Brasileira de Educação e Assistência
Eligibility
Age
40 Years to 59 Years
Inclusion criteria
Inclusion criteria: Adults of both sexes; aged 40 to 59 years; residing in Porto Alegre (RS, Brazil); physically inactive or not engaged in regular physical exercise; in adequate health conditions to undergo the proposed physical and cognitive assessments; able to provide written informed consent; participants with controlled anxiety or depression may be included
Exclusion criteria
Exclusion criteria: Diagnosis of neurodegenerative diseases or severe psychiatric disorders; medical conditions that prevent participation in physical effort tests, biological exams, or cognitive assessments; participation in other clinical studies that may interfere with the results of this research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate whether there will be improvement in muscle strength and physical function after the intervention, verified through isokinetic dynamometry for knee flexor and extensor muscles using the Cybex Humac Norm equipment from CSMi, and through the functional tests Short Physical Performance Battery (SPPB) and Timed Up and Go (TUG), with observation of peak torque in newton meter, flexor extensor strength ratio in percentage, Short Physical Performance Battery score from 0 to 12 points, Timed Up and Go time in seconds, and percentage change between baseline and post intervention;To evaluate whether there will be improvement in metabolic and inflammatory profile after the intervention, verified through laboratory blood tests, with observation of absolute values and changes between pre intervention and post intervention for lipid profile, glucose, insulin, glycated hemoglobin, homocysteine, vitamin D, vitamin B9 or folic acid, thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), C reactive protein, and cortisol;To evaluate whether there will be reduction in body fat and increase in lean mass after the intervention, verified through bioelectrical impedance analysis using the InBody R20 equipment from Biospace, with observation of body fat percentage, fat mass in kilograms, skeletal muscle mass in kilograms, body mass index in kilogram per square meter, and percentage variation between pre intervention and post intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate whether there will be improvement in spatial and temporal gait parameters after the intervention, verified through the P WALK 2.0 baropodometric platform from BTS Bioengineering, with observation of gait speed in meters per second, stride length in centimeters, plantar contact area in square centimeters, single and double stance times in milliseconds, and gait cycle variability expressed as coefficient of variation in percentage;To evaluate whether there will be improvement in subjective and behavioral indicators related to brain health after the intervention, verified through questionnaires applied to the domains of general health, physical activity using the International Physical Activity Questionnaire (IPAQ), cognition, social interactions, sense of purpose using the Daily Activities and Support Scale (DAS 8) and the Mental Health Continuum Short Form (MHC SF), sleep using the Pittsburgh Sleep Quality Index (PSQI), and nutrition using the Nutritional Risk Screening (NRS 2002), with observation of the raw scores of each instrument and the percentage variation between baseline and post intervention | — |
Countries
BR
Contacts
Public ContactJosieli Fraga
Pontifícia Universidade Católica do Rio Grande do Sul
Outcome results
None listed