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Comparison between two types of Progesterone in endometrial preparation for Transfer of Thawed Embryos

Comparison between Micronized Vaginal Progesterone and Oral Didrogesterone in endometrial preparation for Transfer of Thawed Embryos

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
REBEC
Registry ID
RBR-6qycxj
Enrollment
Unknown
Registered
2020-03-31
Start date
2019-12-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility, unespecified

Interventions

Patients will be randomly divided into two groups
a group that will use oral didrogesterone and another micronized vaginal progesterone. Through the sample calculation, the result was 21 per group, considering a power of 90% and a significance level
Drug

Sponsors

Centro de Referência da Saúde da Mulher
Lead Sponsor
Faculdade de Ciências Médicas da Santa Casa de São Paulo
Collaborator

Eligibility

Sex/Gender
Female
Age
21 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients undergoing embryo cryopreservation and thawed embryo transfer due to risk of ovarian hyperstimulation syndrome; excess embryos after pregnancy failure in the fresh transfer; loss of transfer by safe endometrium; who underwent preimplantation genetic testing.

Exclusion criteria

Exclusion criteria: Women with an endometrium smaller than 7 mm after endometrial preparation with estrogen. Patients with a history of recurrent miscarriages; severe male factor; uterine diseases; presence of hydrosalpinx. Patients who had a dominant follicle even with estrogen administration.

Design outcomes

Primary

MeasureTime frame
It is expected to improve the results of assisted reproduction techniques, with an increase in pregnancy rates and live births.

Secondary

MeasureTime frame
It is expected that the patient will be able to choose the progesterone administration route, without loss of treatment effectiveness, improving her satisfaction.

Countries

Brazil

Contacts

Public ContactLuma Macedo

Faculdade de Ciências Médicas da Santa Casa de São Paulo

luma_karol@hotmail.com+55 11 954839491

Outcome results

None listed

Source: REBEC (via WHO ICTRP)