CID-10 'K05.5 Periodontal disease', CID-10 'K053 Chronic periodontitis', CID-10 'C50 Malignant breast neoplasm'.
Conditions
Interventions
The following interventions were performed from our sample of 100 patients (50 with breast cancer and 50 without breast cancer) at 2 phases (before and during chemotherapy of case group) of the resear
radiographic evaluations and periodontal clinical parameters to identify the clinical inflammatory profile in the 2 phases in all patients, the immunohistochemical profile of breast cancer in patients
collection of gingival fluid samples for analysis of inflammatory cytokines IL-8, IL-1ß, TNFa, IL-6 by the ELISA method and subgingival biofilm collection for analysis of the microbiota of Socransky c
2562
Sponsors
Universidade Federal do Espírito Santo
Universidade de Guarulhos
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Women with a confirmed diagnosis of breast cancer and who have not yet started chemotherapy antineoplastic treatment (case group), being over 30 years old, having at least 10 to 15 dental elements, non-smokers, with healthy periodontal degree and with chronic periodontitis, not having other systemic diseases, not having undergone periodontal therapy in the last 6 months and not using antibiotics and anti-inflammatories
Exclusion criteria
Exclusion criteria: Other sistemic disease confirmed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.1. “Expected outcome 1” Higher rates are expected in the cancer group between phases and even after basic periodontal therapy, taking other associated factors as the first starting point, such as: systemic effects of antineoplastic agents and on gingival tissues, aging (cellular senescence), osteoporosis, hormonal change, immunosuppression, of the following data: a- Most of the cancer patients are aged 40 years or more. b- Increased levels of clinical periodontal parameters; c- The proportions of clinical periodontal parameters between the molecular subtypes; d- The inflammatory immune response of periodontal sites; e- In the analysis of the profile of the subgingival microbiota by the Socransky complex between the groups and its relationship with age, level of clinical attachment and tooth loss; 1.a.b. The binomial test for two proportions compared clinical periodontal parameters (PCP) between groups. The chi-square test compared the proportions of periodontal parameters clinical (PPC) between molecular subtypes. The Wilcoxon test compared cytokine concentrations between phases and the Mann-Whitney test for cytokine concentrations (IL8, TNFa, IL6 and IL-1ß) between groups. The Wilcoxon test compared the amount of microbiota >105 between phases. Spearman's correlation associated clinical attachment level (CAL =4mm), age and tooth loss with microbiota. The significance level used was 5%. 1.2. “Outcome Found 1”. a- In our results, most patients were over 40 years of age, b- There were significant differences in periodontal clinical parameters in phase 2 for tooth loss (p=0.01), gingival bleeding index (ISG, p4mm, p 4mm (58.71%), SS (38.57%) ISG (36.39%) and tooth loss (65.71 %) had a higher prevalence for TNBC, confirming our hypothesis of greater expressions of these data in the cancer group and also for the immunohistochemical profile for more aggressive breast cancer at the end of the study. d- When comparing the profile of inflammatory cytokines between gro | — |
Secondary
| Measure | Time frame |
|---|---|
| 2.1. “Expected outcome 2”. a- Associate the possible relationship of clinical attachment level (CIN =4mm) and tooth loss with tumor grade in the entire cancer population. We use simple Poison regression. 2.2. “Outcome found 2”. a- We obtained important results regarding the histological grade for the case group without periodontal disease in relation to tooth loss and CIN, where a patient with histological grade III and II has 4.8 and 3.5 more risks of having a tooth loss in compared to a patient with histological grade I. And a patient with histological grade II and III has the risks to have an increased CIN by 0.5 and 0.4 when compared to a patient with grade I. | — |
Countries
Brazil
Contacts
Public ContactMaria da Conceição Gomes
Outcome results
None listed